Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women

Show full item record



Permalink

http://hdl.handle.net/10138/320315

Citation

Mokkala , K , Juhila , J , Houttu , N , Sorsa , T & Laitinen , K 2020 , ' Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women ' , Heliyon , vol. 6 , no. 8 , 04788 . https://doi.org/10.1016/j.heliyon.2020.e04788

Title: Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
Author: Mokkala, Kati; Juhila, Juuso; Houttu, Noora; Sorsa, Timo; Laitinen, Kirsi
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
Date: 2020-08
Language: eng
Number of pages: 8
Belongs to series: Heliyon
ISSN: 2405-8440
URI: http://hdl.handle.net/10138/320315
Abstract: Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, whether IGFBP-1 and MMP-8 are related to and reflect systemic low-grade inflammation, metabolism and diet. Fasting serum from overweight and obese pregnant women (n = 100) in early pregnancy were analysed for IGFBP-1, phosphorylated IGFBP-1 (phIGFBP-1) and MMP-8. High-sensitivity CRP and GlycA were used as markers for low grade inflammation. GlycA and lipids were quantified using NMR. IGFBP-1 associated negatively with GlycA, evidenced by higher concentrations in the lowest quartile (median 1.53 (IQR 1.45-1.72)) compared to the highest (1.46 (1.39-1.55)) (P = 0.03). Several lipid metabolites, particularly HDL-cholesterol, correlated inversely with phIGFBP-1 (FDR
Subject: Women's health
Pregnancy
Metabolism
Metabolic disorder
Nutrition
Obstetrics & gynecology
IGFBP-1
Insulin
Lipids
MMP-8
FACTOR-BINDING PROTEIN-1
MATRIX METALLOPROTEINASE-8
CIRCULATING LEVELS
GROWTH
WEIGHT
3123 Gynaecology and paediatrics
3121 Internal medicine
3143 Nutrition
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
PIIS2405844020316315.pdf 1.298Mb PDF View/Open
PIIS2405844020320910.pdf 130.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record