Diabetes is associated with familial idiopathic normal pressure hydrocephalus : a case-control comparison with family members

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Räsänen , J , Huovinen , J , Korhonen , V E , Junkkari , A , Kastinen , S , Komulainen , S , Oinas , M , Avellan , C , Frantzen , J , Rinne , J , Ronkainen , A , Kauppinen , M , Lönnrot , K , Perola , M , Koivisto , A M , Remes , A M , Soininen , H , Hiltunen , M , Helisalmi , S , Kurki , M I , Jääskeläinen , J E & Leinonen , V 2020 , ' Diabetes is associated with familial idiopathic normal pressure hydrocephalus : a case-control comparison with family members ' , Fluids and barriers of the CNS , vol. 17 , no. 1 , 57 . https://doi.org/10.1186/s12987-020-00217-0

Title: Diabetes is associated with familial idiopathic normal pressure hydrocephalus : a case-control comparison with family members
Author: Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E.; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M.; Remes, Anne M.; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I.; Jääskeläinen, Juha E.; Leinonen, Ville
Contributor: University of Helsinki, Clinicum
University of Helsinki, Neurokirurgian yksikkö
University of Helsinki, HUS Neurocenter
University of Helsinki, University of Helsinki
University of Helsinki, Massachusetts General Hospital
Date: 2020-09-15
Language: eng
Number of pages: 11
Belongs to series: Fluids and barriers of the CNS
ISSN: 2045-8118
URI: http://hdl.handle.net/10138/320414
Abstract: Background The pathophysiological basis of idiopathic normal pressure hydrocephalus (iNPH) is still unclear. Previous studies have shown a familial aggregation and a potential heritability when it comes to iNPH. Our aim was to conduct a novel case-controlled comparison between familial iNPH (fNPH) patients and their elderly relatives, involving multiple different families. Methods Questionnaires and phone interviews were used for collecting the data and categorising the iNPH patients into the familial (fNPH) and the sporadic groups. Identical questionnaires were sent to the relatives of the potential fNPH patients. Venous blood samples were collected for genetic studies. The disease histories of the probable fNPH patients (n = 60) were compared with their >= 60-year-old relatives with no iNPH (n = 49). A modified Charlson Comorbidity Index (CCI) was used to measure the overall disease burden. Fisher's exact test (two-tailed), the Mann-Whitney U test (two-tailed) and a multivariate binary logistic regression analysis were used to perform the statistical analyses. Results Diabetes (32% vs. 14%, p = 0.043), arterial hypertension (65.0% vs. 43%, p = 0.033), cardiac insufficiency (16% vs. 2%, p = 0.020) and depressive symptoms (32% vs. 8%, p = 0.004) were overrepresented among the probable fNPH patients compared to their non-iNPH relatives. In the age-adjusted multivariate logistic regression analysis, diabetes remained independently associated with fNPH (OR = 3.8, 95% CI 1.1-12.9, p = 0.030). Conclusions Diabetes is associated with fNPH and a possible risk factor for fNPH. Diabetes could contribute to the pathogenesis of iNPH/fNPH, which motivates to further prospective and gene-environmental studies to decipher the disease modelling of iNPH/fNPH.
Subject: Normal pressure hydrocephalus
Familial
Comorbidities
Diabetes
Depression
Genetics
SFMBT1
VASCULAR RISK-FACTORS
GLYMPHATIC SYSTEM
INPH
MRI
NPH
EPIDEMIOLOGY
IMPAIRMENT
SYMPTOMS
MELLITUS
FEATURES
3112 Neurosciences
3124 Neurology and psychiatry
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