Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia

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Pekkala , T , Hall , A , Mangialasche , F , Kemppainen , N , Mecocci , P , Ngandu , T , Rinne , J O , Soininen , H , Tuomilehto , J , Kivipelto , M & Solomon , A 2020 , ' Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia ' , Journal of Alzheimer's Disease , vol. 76 , no. 4 , pp. 1243-1248 . https://doi.org/10.3233/JAD-200145

Title: Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia
Author: Pekkala, Timo; Hall, Anette; Mangialasche, Francesca; Kemppainen, Nina; Mecocci, Patrizia; Ngandu, Tiia; Rinne, Juha O.; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto, Miia; Solomon, Alina
Contributor: University of Helsinki, Clinicum
Date: 2020
Language: eng
Number of pages: 6
Belongs to series: Journal of Alzheimer's Disease
ISSN: 1387-2877
URI: http://hdl.handle.net/10138/320432
Abstract: We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOE epsilon 4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.
Subject: Amyloid-beta
apolipoprotein E
plasminogen activator
positron emission tomography
type 2 diabetes
DISEASE
SCORE
3112 Neurosciences
3124 Neurology and psychiatry
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