Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America : An individual participant data meta-analysis of 229,000 singleton births

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dc.contributor.author Philips, Elise M.
dc.contributor.author Santos, Susana
dc.contributor.author Trasande, Leonardo
dc.contributor.author Aurrekoetxea, Juan J.
dc.contributor.author Barros, Henrique
dc.contributor.author von Berg, Andrea
dc.contributor.author Bergstroem, Anna
dc.contributor.author Bird, Philippa K.
dc.contributor.author Brescianini, Sonia
dc.contributor.author Chaoimh, Carol Ni
dc.contributor.author Charles, Marie-Aline
dc.contributor.author Chatzi, Leda
dc.contributor.author Chevrier, Cecile
dc.contributor.author Chrousos, George P.
dc.contributor.author Costet, Nathalie
dc.contributor.author Criswell, Rachel
dc.contributor.author Crozier, Sarah
dc.contributor.author Eggesbo, Merete
dc.contributor.author Fantini, Maria Pia
dc.contributor.author Farchi, Sara
dc.contributor.author Forastiere, Francesco
dc.contributor.author van Gelder, Marleen M. H. J.
dc.contributor.author Georgiu, Vagelis
dc.contributor.author Godfrey, Keith M.
dc.contributor.author Gori, Davide
dc.contributor.author Hanke, Wojciech
dc.contributor.author Heude, Barbara
dc.contributor.author Hryhorczuk, Daniel
dc.contributor.author Iniguez, Carmen
dc.contributor.author Inskip, Hazel
dc.contributor.author Karvonen, Anne M.
dc.contributor.author Kenny, Louise C.
dc.contributor.author Kull, Inger
dc.contributor.author Lawlor, Debbie A.
dc.contributor.author Lehmann, Irina
dc.contributor.author Magnus, Per
dc.contributor.author Manios, Yannis
dc.contributor.author Melen, Erik
dc.contributor.author Mommers, Monique
dc.contributor.author Morgen, Camilla S.
dc.contributor.author Moschonis, George
dc.contributor.author Murray, Deirdre
dc.contributor.author Nohr, Ellen A.
dc.contributor.author Andersen, Anne-Marie Nybo
dc.contributor.author Oken, Emily
dc.contributor.author Oostvogels, Adriette J. J. M.
dc.contributor.author Papadopoulou, Eleni
dc.contributor.author Pekkanen, Juha
dc.contributor.author Pizzi, Costanza
dc.contributor.author Polanska, Kinga
dc.contributor.author Porta, Daniela
dc.contributor.author Richiardi, Lorenzo
dc.contributor.author Rifas-Shiman, Sheryl L.
dc.contributor.author Roeleveld, Nel
dc.contributor.author Rusconi, Franca
dc.contributor.author Santos, Ana C.
dc.contributor.author Sorensen, Thorkild I. A.
dc.contributor.author Standl, Marie
dc.contributor.author Stoltenberg, Camilla
dc.contributor.author Sunyer, Jordi
dc.contributor.author Thiering, Elisabeth
dc.contributor.author Thijs, Carel
dc.contributor.author Torrent, Maties
dc.contributor.author Vrijkotte, Tanja G. M.
dc.contributor.author Wright, John
dc.contributor.author Zvinchuk, Oleksandr
dc.contributor.author Gaillard, Romy
dc.contributor.author Jaddoe, Vincent W. V.
dc.date.accessioned 2020-10-21T07:41:01Z
dc.date.available 2020-10-21T07:41:01Z
dc.date.issued 2020-08
dc.identifier.citation Philips , E M , Santos , S , Trasande , L , Aurrekoetxea , J J , Barros , H , von Berg , A , Bergstroem , A , Bird , P K , Brescianini , S , Chaoimh , C N , Charles , M-A , Chatzi , L , Chevrier , C , Chrousos , G P , Costet , N , Criswell , R , Crozier , S , Eggesbo , M , Fantini , M P , Farchi , S , Forastiere , F , van Gelder , M M H J , Georgiu , V , Godfrey , K M , Gori , D , Hanke , W , Heude , B , Hryhorczuk , D , Iniguez , C , Inskip , H , Karvonen , A M , Kenny , L C , Kull , I , Lawlor , D A , Lehmann , I , Magnus , P , Manios , Y , Melen , E , Mommers , M , Morgen , C S , Moschonis , G , Murray , D , Nohr , E A , Andersen , A-M N , Oken , E , Oostvogels , A J J M , Papadopoulou , E , Pekkanen , J , Pizzi , C , Polanska , K , Porta , D , Richiardi , L , Rifas-Shiman , S L , Roeleveld , N , Rusconi , F , Santos , A C , Sorensen , T I A , Standl , M , Stoltenberg , C , Sunyer , J , Thiering , E , Thijs , C , Torrent , M , Vrijkotte , T G M , Wright , J , Zvinchuk , O , Gaillard , R & Jaddoe , V W V 2020 , ' Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America : An individual participant data meta-analysis of 229,000 singleton births ' , PLoS Medicine , vol. 17 , no. 8 , 1003182 . https://doi.org/10.1371/journal.pmed.1003182
dc.identifier.other PURE: 145327133
dc.identifier.other PURE UUID: 5570aa94-a852-44e9-bb84-4ae580548022
dc.identifier.other WOS: 000563452200005
dc.identifier.uri http://hdl.handle.net/10138/320496
dc.description.abstract Author summaryWhy was this study done? Maternal smoking during pregnancy is an important risk factor for various birth complications and childhood overweight. It is not clear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy. The associations of paternal smoking with birth and childhood outcomes also remain unknown. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 229,158 families from 28 pregnancy and birth cohorts from Europe and North America to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. We observed that smoking in the first trimester only did not increase the risk of preterm birth and small size for gestational age but was associated with a higher risk of childhood overweight, as compared to nonsmoking. Reducing the number of cigarettes during pregnancy, without quitting, was still associated with higher risks of these adverse outcomes. Paternal smoking seems to be associated, independently of maternal smoking, with the risks of childhood overweight. What do these findings mean? Population strategies should focus on parental smoking prevention before or at the start of, rather than during, pregnancy. Future studies are needed to assess the specific associations of smoking in the preconception and childhood periods with offspring outcomes. Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers' median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02-1.35],Pvalue = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02-1.15],Pvalue = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07-2.23],Pvalue <0.001), and childhood overweight (OR 1.42 [95% CI 1.35-1.48],Pvalue <0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52-2.34] instead of OR 2.20 [95% CI 2.02-2.42] when reducing from 5-9 to = 10 to 5-9 and en
dc.format.extent 25
dc.language.iso eng
dc.relation.ispartof PLoS Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject MATERNAL SMOKING
dc.subject PRETERM BIRTH
dc.subject DNA METHYLATION
dc.subject ASSOCIATION
dc.subject WEIGHT
dc.subject GROWTH
dc.subject EXPOSURE
dc.subject CHILDREN
dc.subject CESSATION
dc.subject OBESITY
dc.subject 3142 Public health care science, environmental and occupational health
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America : An individual participant data meta-analysis of 229,000 singleton births en
dc.type Article
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pmed.1003182
dc.relation.issn 1549-1277
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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