Persistent and changing job strain and risk of coronary heart disease. A population-based cohort study of 1.6 million employees in Denmark

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dc.contributor.author Rugulies, Reiner
dc.contributor.author Framke, Elisabeth
dc.contributor.author Sorensen, Jeppe Karl
dc.contributor.author Svane-Petersen, Annemette Coop
dc.contributor.author Alexanderson, Kristina
dc.contributor.author Bonde, Jens Peter
dc.contributor.author Farrants, Kristin
dc.contributor.author Flachs, Esben Meulengracht
dc.contributor.author Hanson, Linda L. Magnusson
dc.contributor.author Nyberg, Solja T.
dc.contributor.author Kivimäki, Mika
dc.contributor.author Madsen, Ida E. H.
dc.date.accessioned 2020-10-21T11:13:01Z
dc.date.available 2020-10-21T11:13:01Z
dc.date.issued 2020
dc.identifier.citation Rugulies , R , Framke , E , Sorensen , J K , Svane-Petersen , A C , Alexanderson , K , Bonde , J P , Farrants , K , Flachs , E M , Hanson , L L M , Nyberg , S T , Kivimäki , M & Madsen , I E H 2020 , ' Persistent and changing job strain and risk of coronary heart disease. A population-based cohort study of 1.6 million employees in Denmark ' , Scandinavian Journal of Work, Environment & Health , vol. 46 , no. 5 , pp. 498-507 . https://doi.org/10.5271/sjweh.3891
dc.identifier.other PURE: 145371935
dc.identifier.other PURE UUID: 8ad5bc57-d7b4-4947-86bc-cf436ee1bb6f
dc.identifier.other WOS: 000566336200007
dc.identifier.uri http://hdl.handle.net/10138/320506
dc.description.abstract Objectives This study aimed to examine the association between job strain and incident coronary heart disease (CHD) in Denmark, while accounting for changes of job strain. Methods We included all employees residing in Denmark in 2000, aged 30-59 years with no prevalent CHD (N=1660 150). We determined exposure to job strain from 1996-2009 using a job exposure matrix (JEM) with annual updates. Follow-up for incident CHD was from 2001-2010 via linkage to health records. We used Cox regression to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the association between job strain and incident CHD. Results During 16.1 million person-years, we identified 24 159 incident CHD cases (15.0 per 10 000 person-years). After adjustment for covariates, job strain in 2000 predicted onset of CHD during a mean follow-up of 9.71 years (HR 1.10, 95% CI 1.07-1.13). When analyzing changes in job strain from one year to the next and CHD in the subsequent year, persistent job strain (HR 1.07, 95% CI 1.03-1.10), onset of job strain (HR 1.20, 95% CI 1.12-1.29) and removal of strain (HR 1.20, 95% CI 1.12-1.28) were associated with higher CHD incidence compared to persistent no job strain. Associations were similar among men and women. Conclusions Job strain is associated with a higher risk of incident CHD in Denmark. As we used a JEM, we can rule out reporting bias. However, under- or overestimation of associations is possible due to non-differential misclassification of job strain and residual confounding by socioeconomic position. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Scandinavian Journal of Work, Environment & Health
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject cardiovascular disease
dc.subject CHD
dc.subject epidemiology
dc.subject JEM
dc.subject job control
dc.subject job exposure matrix
dc.subject psychological demand
dc.subject psychosocial work environment
dc.subject stress
dc.subject work stress
dc.subject ACUTE MYOCARDIAL-INFARCTION
dc.subject WORK-ENVIRONMENT
dc.subject CARDIOVASCULAR-DISEASE
dc.subject DANISH REGISTERS
dc.subject EXPOSURE MATRIX
dc.subject HEALTH
dc.subject CHALLENGES
dc.subject MORTALITY
dc.subject VALIDITY
dc.subject TRENDS
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Persistent and changing job strain and risk of coronary heart disease. A population-based cohort study of 1.6 million employees in Denmark en
dc.type Article
dc.contributor.organization Department of Biochemistry and Developmental Biology
dc.contributor.organization Clinicum
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.5271/sjweh.3891
dc.relation.issn 0355-3140
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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