Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals

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Palmu, J, Salosensaari, A, Havulinna, A S, Cheng, S, Inouye, M, Jain, M, Salido, R A, Sanders, K, Brennan, C, Humphrey, G C, Sanders, J G, Vartiainen, E, Laatikainen, T, Jousilahti, P, Salomaa, V, Knight, R, Lahti, L & Niiranen, T J 2020, ' Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals ', Journal of the American Heart Association, vol. 9, no. 15, 016641 . https://doi.org/10.1161/JAHA.120.016641

Title: Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals
Author: Palmu, Joonatan; Salosensaari, Aaro; Havulinna, Aki S.; Cheng, Susan; Inouye, Michael; Jain, Mohit; Salido, Rodolfo A.; Sanders, Karenina; Brennan, Caitriona; Humphrey, Gregory C.; Sanders, Jon G.; Vartiainen, Erkki; Laatikainen, Tiina; Jousilahti, Pekka; Salomaa, Veikko; Knight, Rob; Lahti, Leo; Niiranen, Teemu J.
Contributor organization: Medicum
Institute for Molecular Medicine Finland
Complex Disease Genetics
Helsinki Institute of Life Science HiLIFE
Date: 2020-08-04
Language: eng
Number of pages: 33
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.120.016641
URI: http://hdl.handle.net/10138/320534
Abstract: Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representative, well-phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations between sodium intake and Lactobacillus abundance and between Lactobacillus abundance and BP. Methods and Results We studied a population sample of 6953 Finns aged 25 to 74 years (mean age, 49.212.9 years; 54.9% women). The participants underwent a health examination, which included BP measurement, stool collection, and 24-hour urine sampling (N=829). Gut microbiota was analyzed using shallow shotgun metagenome sequencing. In age- and sex-adjusted models, the alpha (within-sample) and beta (between-sample) diversities of taxonomic composition were strongly related to BP indexes (P diversity was only associated with diastolic BP (P=0.032). However, we observed significant, mainly positive, associations between BP indexes and 45 microbial genera (P Conclusions Although the associations between overall gut taxonomic composition and BP are weak, individuals with hypertension demonstrate changes in several genera. We demonstrate strong negative associations of certain Lactobacillus species with sodium intake and BP, highlighting the need for experimental studies.
Subject: blood pressure
gastrointestinal microbiota
hypertension
Lactobacillus
salt intake
HYPERTENSION
HEALTH
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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