Shared PKS Module in Biosynthesis of Synergistic Laxaphycins

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Heinilä , L , Fewer , D , Jokela , J , Wahlsten , M , Jortikka , A E & Sivonen , K 2020 , ' Shared PKS Module in Biosynthesis of Synergistic Laxaphycins ' , Frontiers in Microbiology , vol. 11 , 578878 . https://doi.org/10.3389/fmicb.2020.578878

Title: Shared PKS Module in Biosynthesis of Synergistic Laxaphycins
Author: Heinilä, Lassi; Fewer, David; Jokela, Jouni; Wahlsten, Matti; Jortikka, Anna Elisabeth; Sivonen, Kaarina
Contributor: University of Helsinki, Department of Microbiology
University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS)
University of Helsinki, Faculty of Agriculture and Forestry
University of Helsinki, Department of Microbiology
University of Helsinki, Department of Microbiology
University of Helsinki, Helsinki Institute of Sustainability Science (HELSUS)
Date: 2020-09-16
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Microbiology
ISSN: 1664-302X
URI: http://hdl.handle.net/10138/320549
Abstract: Cyanobacteria produce a wide range of lipopeptides that exhibit potent membrane-disrupting activities. Laxaphycins consist of two families of structurally distinct macrocyclic lipopeptides that act in a synergistic manner to produce antifungal and antiproliferative activities. Laxaphycins are produced by range of cyanobacteria but their biosynthetic origins remain unclear. Here, we identified the biosynthetic pathways responsible for the biosynthesis of the laxaphycins produced by Scytonema hofmannii PCC 7110. We show that these laxaphycins, called scytocyclamides, are produced by this cyanobacterium and are encoded in a single biosynthetic gene cluster with shared polyketide synthase enzymes initiating two distinct non-ribosomal peptide synthetase pathways. The unusual mechanism of shared enzymes synthesizing two distinct types of products may aid future research in identifying and expressing natural product biosynthetic pathways and in expanding the known biosynthetic logic of this important family of natural products.
Subject: 11832 Microbiology and virology
Synergy
Biosynthesis
Dehydrobutyrine
Natural Product
Cupin
Laxaphycin
Scytocyclamide
Antifungal
synergy
biosynthesis
natural product
laxaphycin
scytocyclamide
antifungal
cupin
dehydrobutyrine
NONRIBOSOMAL PEPTIDE SYNTHETASES
ANTIFUNGAL CYCLIC-PEPTIDES
ALGA ANABAENA-LAXA
GENE-CLUSTER
NATURAL-PRODUCTS
CYANOBACTERIA
LIPOPEPTIDES
ANABAENOPEPTIN
TRICHORMAMIDES
IDENTIFICATION
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