A novel negevirus isolated from Aedes vexans mosquitoes in Finland

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Suvanto , M T , Truong Nguyen , P , Uusitalo , R , Korhonen , E M , Faolotto , G , Vapalahti , O , Huhtamo , E & Smura , T 2020 , ' A novel negevirus isolated from Aedes vexans mosquitoes in Finland ' , Archives of Virology , vol. 165 , no. 12 , pp. 2989–2992 . https://doi.org/10.1007/s00705-020-04810-4

Title: A novel negevirus isolated from Aedes vexans mosquitoes in Finland
Author: Suvanto, Maija T.; Truong Nguyen, Phuoc; Uusitalo, Ruut; Korhonen, Essi M.; Faolotto, Giulia; Vapalahti, Olli; Huhtamo, Eili; Smura, Teemu
Contributor organization: Department of Virology
Veterinary Biosciences
Department of Geosciences and Geography
Viral Zoonosis Research Unit
Helsinki One Health (HOH)
Veterinary Microbiology and Epidemiology
Date: 2020-12
Language: eng
Number of pages: 4
Belongs to series: Archives of Virology
ISSN: 0304-8608
DOI: https://doi.org/10.1007/s00705-020-04810-4
URI: http://hdl.handle.net/10138/320668
Abstract: Negeviruses are insect-specific enveloped RNA viruses that have been detected in mosquitoes and sandflies from various geographical locations. Here, we describe a new negevirus from Northern Europe, isolated from pool ofAedes vexansmosquitoes collected in Finland, designated as Mekrijarvi negevirus (MEJNV). MEJNV had a typical negevirus genome organization, is 9,740 nucleotides in length, and has a GC content of 47.53%. The MEJNV genome contains three ORFs, each containing the following identified conserved domains: ORF1 (7,068 nt) encodes a viral methyltransferase, an FtsJ-like methyltransferase, a viral RNA helicase, and an RNA-dependent RNA polymerase, ORF2 (1,242 nt) encodes a putative virion glycoprotein, and ORF3 (660 nt) encodes a putative virion membrane protein. A distinctive feature relative to other currently known negeviruses is a 7-nucleotide-long overlap between ORF1 and ORF2. MEJNV shares the highest sequence identity with Ying Kou virus from China, with 67.71% nucleotide and 75.19% and 59.00% amino acid sequence identity in ORF 1 and ORF 2, respectively. ORF3 had the highest amino acid sequence similarity to Daeseongdong virus 1 and negevirus Nona 1, both with 77.61% identity, and to Ying Kou virus, with 71.22% identity. MEJNV is currently the northernmost negevirus described. Our report supports the view that negeviruses are a globally distributed, diverse group of viruses that can be found from mosquitoes in a wide range of terrestrial biomes from tropical to boreal forests.
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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