The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia

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http://hdl.handle.net/10138/320709

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Vakkilainen , S , Kleino , I , Honkanen , J , Salo , H , Kainulainen , L , Gräsbeck , M , Kekäläinen , E , Mäkitie , O & Klemetti , P 2020 , ' The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia ' , Frontiers in Immunology , vol. 11 , 2020 . https://doi.org/10.3389/fimmu.2020.02020

Title: The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia
Author: Vakkilainen, Svetlana; Kleino, Iivari; Honkanen, Jarno; Salo, Harri; Kainulainen, Leena; Gräsbeck, Michaela; Kekäläinen, Eliisa; Mäkitie, Outi; Klemetti, Paula
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Research Programs Unit
Faculty of Medicine
TRIMM - Translational Immunology Research Program
Clinicum
Kymsote – Social and Health Services in Kymenlaakso
HYKS erva
HUSLAB
Lastentautien yksikkö
Date: 2020-08-11
Language: eng
Number of pages: 8
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.02020
URI: http://hdl.handle.net/10138/320709
Abstract: Background: Live viral vaccines are generally contraindicated in patients with combined immunodeficiency including cartilage-hair hypoplasia (CHH); however, they may be tolerated in milder syndromes. We evaluated the safety and efficacy of live viral vaccines in patients with CHH. Methods: We analyzed hospital and immunization records of 104 patients with CHH and measured serum antibodies to measles, mumps, rubella, and varicella zoster virus (VZV) in all patients who agreed to blood sampling (n= 50). We conducted a clinical trial (identifier: NCT02383797) of live VZV vaccine on five subjects with CHH who lacked varicella history, had no clinical symptoms of immunodeficiency, and were seronegative for VZV; humoral and cellular immunologic responses were assessed post-immunization. Results: A large proportion of patients have been immunized with live viral vaccines, including measles-mumps-rubella (MMR) (n= 40, 38%) and VZV (n= 10, 10%) vaccines, with no serious adverse events. Of the 50 patients tested for antibodies, previous immunization has been documented with MMR (n= 22), rubella (n= 2) and measles (n= 1) vaccines. Patients with CHH demonstrated seropositivity rates of 96%/75%/91% to measles, mumps and rubella, respectively, measured at a medium of 24 years post-immunization. Clinical trial participants developed humoral and cellular responses to VZV vaccine. One trial participant developed post-immunization rash and knee swelling, both resolved without treatment. Conclusion: No serious adverse events have been recorded after immunization with live viral vaccines in Finnish patients with CHH. Patients generate humoral and cellular immune response to live viral vaccines. Immunization with live vaccines may be considered in selected CHH patients with no or clinically mild immunodeficiency.
Subject: clinical trial
combined immunodeficiency
immunization
MMR
RMRP
vaccination
varicella zoster virus
VARICELLA VACCINE
RNASE-MRP
IMMUNODEFICIENCY
MUTATIONS
PHENOTYPE
CHILDREN
AMISH
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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