Maternal Diabetes and Risk of Childhood Cancer in the Offspring

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Seppälä , L K , Vettenranta , K , Pitkäniemi , J , Hirvonen , E , Leinonen , M K & Madanat-Harjuoja , L-M 2020 , ' Maternal Diabetes and Risk of Childhood Cancer in the Offspring ' , International Journal of Cancer , vol. 147 , no. 3 , pp. 662-668 . https://doi.org/10.1002/ijc.32757

Title: Maternal Diabetes and Risk of Childhood Cancer in the Offspring
Author: Seppälä, Laura K.; Vettenranta, Kim; Pitkäniemi, Janne; Hirvonen, Elli; Leinonen, Maarit K.; Madanat-Harjuoja, Laura-Maria
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Clinicum
Date: 2020-08-01
Language: eng
Number of pages: 7
Belongs to series: International Journal of Cancer
ISSN: 0020-7136
URI: http://hdl.handle.net/10138/320718
Abstract: An association between maternal diabetes, its medication and childhood cancer has not been previously explored in a registry-based setting. With a case-control design, we aimed to explore whether maternal diabetes is associated with an increased risk of childhood cancer in the offspring. Combining data from population-based registries, we analyzed a total of 2,029 cases, i.e. persons with childhood cancer diagnosed under the age of 20?years between years 1996-2014 and a total of 10,103 matched population controls. The mothers of the cases/controls and their diagnoses of diabetes (DM) before/during pregnancy as well as their insulin/metformin prescriptions during pregnancy were identified. Conditional logistic regression modelling was used to analyze the risk of childhood cancer. The OR for childhood cancer among those exposed to any maternal diabetes was 1.32 (95% CI 1.14-1.54) compared to the offspring of the non-diabetic mothers. The effect of maternal diabetes on the risk of childhood cancer remained elevated even after adjusting for maternal age, parity and smoking. Our data suggest that maternal diabetes medication may reduce the risk for childhood cancer (adjusted OR 0.83, 95% CI 0.36-1.94), especially in gestational diabetes (adjusted OR 0.26, 95% CI 0.05-1.25), compared to the diabetic mothers without medication. The risk of childhood leukemia was significantly higher among children exposed to any maternal diabetes (OR 1.36, CI 1.04-1.77) compared to the unexposed. Maternal diabetes appears to be associated with an increased risk of childhood cancer in the offspring. The possible risk-reducing effect of an exposure to diabetes medication on offspring cancer risk warrants further investigation. This article is protected by copyright. All rights reserved.
Subject: 3122 Cancers
childhood cancer
maternal diabetes
medication
insulin
metformin
in utero exposure
METFORMIN
BIRTH-WEIGHT
INSULIN-RECEPTORS
CHILDREN
OBESITY
ACUTE LYMPHOBLASTIC-LEUKEMIA
DISEASE
POOLED ANALYSIS
COHORT
ASSOCIATION
3123 Gynaecology and paediatrics
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