Anaphylaxis in pregnancy : a population-based multinational European study

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INOSS Collaboration , McCall , S J , Bonnet , M-P , Äyräs , O & Knight , M 2020 , ' Anaphylaxis in pregnancy : a population-based multinational European study ' , Anaesthesia , vol. 75 , no. 11 , pp. 1469-1475 .

Title: Anaphylaxis in pregnancy : a population-based multinational European study
Author: INOSS Collaboration; McCall, S. J.; Bonnet, M-P; Äyräs, O.; Knight, M.
Contributor organization: Faculty of Medicine
HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Helsinki University Hospital Area
Date: 2020-11
Language: eng
Number of pages: 7
Belongs to series: Anaesthesia
ISSN: 0003-2409
Abstract: Anaphylaxis in pregnancy is a rare but severe complication for both mother and infant. Population-based data on anaphylaxis in pregnancy are lacking from mainland European countries. This multinational study presents the incidence, causative agents, management and maternal and infant outcomes of anaphylaxis in pregnancy. This descriptive multinational study used a combination of retrospective (Finnish medical registries) and prospective population-based studies (UK, France, Belgium and the Netherlands) to identify cases of anaphylaxis. Sixty-five cases were identified among 4,446,120 maternities (1.5 per 100,000 maternities; 95%CI 1.1-1.9). The incidence did not vary between countries. Approximately three-quarters of reactions occurred at the time of delivery. The most common causes were antibiotics in 27 women (43%), and anaesthetic agents in 11 women (17%; including neuromuscular blocking drugs, 7), which varied between countries. Anaphylaxis had very poor outcomes for one in seven mothers and one in seven babies; the maternal case fatality rate was 3.2% (95%CI 0.4-11.0) and the neonatal encephalopathy rate was 14.3% (95%CI 4.8-30.3). Across Europe, anaphylaxis related to pregnancy is rare despite having a multitude of causative agents and different antibiotic prophylaxis protocols.
Subject: anaphylaxis causative agents
anaphylaxis in pregnancy
anaphylaxis management
maternal morbidity
neonatal encephalopathy
neuromuscular blocking drugs
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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