Sex-specific association between infant caudate volumes and a polygenic risk score for major depressive disorder

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Acosta , H , Kantojarvi , K , Tuulari , J J , Lewis , J D , Hashempour , N , Scheinin , N M , Lehtola , S J , Fonov , V S , Collins , D L , Evans , A , Parkkola , R , Lähdesmäki , T , Saunavaara , J , Merisaari , H , Karlsson , L , Paunio , T & Karlsson , H 2020 , ' Sex-specific association between infant caudate volumes and a polygenic risk score for major depressive disorder ' , Journal of Neuroscience Research , vol. 98 , no. 12 , pp. 2529-2540 . https://doi.org/10.1002/jnr.24722

Title: Sex-specific association between infant caudate volumes and a polygenic risk score for major depressive disorder
Author: Acosta, Henriette; Kantojarvi, Katri; Tuulari, Jetro J.; Lewis, John D.; Hashempour, Niloofar; Scheinin, Noora M.; Lehtola, Satu J.; Fonov, Vladimir S.; Collins, D. Louis; Evans, Alan; Parkkola, Riitta; Lähdesmäki, Tuire; Saunavaara, Jani; Merisaari, Harri; Karlsson, Linnea; Paunio, Tiina; Karlsson, Hasse
Contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, HUS Psychiatry
University of Helsinki, University of Turku
Date: 2020-12
Language: eng
Number of pages: 12
Belongs to series: Journal of Neuroscience Research
ISSN: 0360-4012
URI: http://hdl.handle.net/10138/320824
Abstract: Polygenic risk scores for major depressive disorder (PRS-MDD) have been identified in large genome-wide association studies, and recent findings suggest that PRS-MDD might interact with environmental risk factors to shape human limbic brain development as early as in the prenatal period. Striatal structures are crucially involved in depression; however, the association of PRS-MDD with infant striatal volumes is yet unknown. In this study, 105 Finnish mother-infant dyads (44 female, 11-54 days old) were investigated to reveal how infant PRS-MDD is associated with infant dorsal striatal volumes (caudate, putamen) and whether PRS-MDD interacts with prenatal maternal depressive symptoms (Edinburgh Postnatal Depression Scale, gestational weeks 14, 24, 34) on infant striatal volumes. A robust sex-specific main effect of PRS-MDD on bilateral infant caudate volumes was observed. PRS-MDD were more positively associated with caudate volumes in boys compared to girls. No significant interaction effects of genotype PRS-MDD with the environmental risk factor "prenatal maternal depressive symptoms" (genotype-by-environment interaction) nor significant interaction effects of genotype with prenatal maternal depressive symptoms and sex (genotype-by-environment-by-sex interaction) were found for infant dorsal striatal volumes. Our study showed that a higher PRS-MDD irrespective of prenatal exposure to maternal depressive symptoms is associated with smaller bilateral caudate volumes, an indicator of greater susceptibility to major depressive disorder, in female compared to male infants. This sex-specific polygenic effect might lay the ground for the higher prevalence of depression in women compared to men.
Subject: brain development
Gene-environment interaction
MRI
prenatal programming
striatum
BRAIN
DIMORPHISM
ABNORMALITIES
SEGMENTATION
PHENOTYPES
IMPUTATION
PREGNANCY
SYMPTOMS
HORMONES
DISEASE
3112 Neurosciences
3124 Neurology and psychiatry
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