Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study

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Måseide , R J , Berntorp , E , Astermark , J , Olsson , A , Bruzelius , M , Frisk , T , Nummi , V , Lassila , R , Tjonnfjord , G E & Holme , P A 2020 , ' Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study ' , Haemophilia , vol. 26 , no. 5 , pp. 891-897 . https://doi.org/10.1111/hae.14114

Title: Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study
Author: Måseide, Ragnhild J.; Berntorp, Erik; Astermark, Jan; Olsson, Anna; Bruzelius, Maria; Frisk, Tony; Nummi, Vuokko; Lassila, Riitta; Tjonnfjord, Geir E.; Holme, Pål A.
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
Date: 2020-09
Language: eng
Number of pages: 7
Belongs to series: Haemophilia
ISSN: 1351-8216
URI: http://hdl.handle.net/10138/320826
Abstract: Introduction The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known. Aim We evaluated joint health in Nordic patients in relation to their treatment modality. Methods A cross-sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS). Results We report on 145 patients: median age 28 years (IQR 13-52) and 61% MHA. Baseline factor VIII/factor IX activity (FVIII/FIX:C) was 2 IU/dL (median) (IQR 2-4): lower for MHB (2 IU/dL, IQR 1-2) than MHA (3 IU/dL, IQR 2-4) (P <.01). Eighty-five per cent of MHA and 73% MHB had a history of haemarthrosis (P = .07). Age at first joint bleed was lower for MHA (5 years [median], IQR 3-7) than MHB (7 years, IQR 5-12) (P = .01). Thirty-eight per cent received prophylaxis, started at median 10 years of age (IQR 4-24). Median joint bleeds and serious other bleeds during the last 12 months were both zero (IQR 0-1). Total HEAD-US captured 0/48 points (median) (IQR 0-2) and HJHS 4/120 points (IQR 1-10) with strong correlation between them (r = .72). FVIII/FIX:C
Subject: arthropathy
joint score
moderate haemophilia A
moderate haemophilia B
prophylaxis
ultrasound
EARLY ARTHROPATHY DETECTION
CLINICAL SEVERITY
PROPHYLACTIC TREATMENT
ROUTINE HEMOPHILIA
SCORE
ULTRASOUND
CHILDREN
ADULTS
RATES
3121 General medicine, internal medicine and other clinical medicine
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