Clinically relevant drug-drug interactions and the risk for drug adverse effects among home-dwelling older persons with and without type 2 diabetes

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Ikäheimo , I , Karjalainen , M , Tiihonen , M , Haanpää , M , Kautiainen , H , Saltevo , J & Mäntyselkä , P 2019 , ' Clinically relevant drug-drug interactions and the risk for drug adverse effects among home-dwelling older persons with and without type 2 diabetes ' , Journal of Clinical Pharmacy and Therapeutics , vol. 44 , no. 5 , pp. 735-741 . https://doi.org/10.1111/jcpt.12854

Title: Clinically relevant drug-drug interactions and the risk for drug adverse effects among home-dwelling older persons with and without type 2 diabetes
Author: Ikäheimo, Ilona; Karjalainen, Merja; Tiihonen, Miia; Haanpää, Maija; Kautiainen, Hannu; Saltevo, Juha; Mäntyselkä, Pekka
Other contributor: University of Helsinki, HUS Neurocenter
University of Helsinki, Clinicum




Date: 2019-10
Language: eng
Number of pages: 7
Belongs to series: Journal of Clinical Pharmacy and Therapeutics
ISSN: 0269-4727
DOI: https://doi.org/10.1111/jcpt.12854
URI: http://hdl.handle.net/10138/320953
Abstract: What is known and objective Polypharmacy and age are known to increase the risk for potential drug interactions. Type 2 diabetes has been associated with polypharmacy and several comorbidities. Currently, there is no information on whether the frequency of clinically relevant drug-drug interactions and the risk for drug adverse effects differ between older persons with and without diabetes. The aim of this study was to investigate the frequency of drug-drug interactions and the risk for drug adverse effects in these two groups in primary care. Methods The basic study population consisted of Finnish home-dwelling primary care patients aged >= 65 years (N = 3039). For each person with diabetes, two controls were selected with adjusted age and gender. To collect data, electronic primary care patient records, a structured health questionnaire and a structured health examination conducted by a physician were utilized. Using the SFINX-PHARAO (R) database, drug-drug interactions and the risk for drug adverse effects were evaluated in 182 persons with type 2 diabetes and 176 persons without diabetes. Results and discussion There were no significant differences in the frequency of drug-drug interactions or the risk for drug adverse effects in persons with and without diabetes. At least one clinically relevant interaction was found in 81 (44.5%) persons with diabetes and 73 (41.5%) persons without diabetes. The most common drugs causing interactions included non-steroidal anti-inflammatory drugs (NSAIDs) and warfarin. What is new and conclusion There is no difference in the frequency of drug-drug interactions or risk for drug adverse effects in older home-dwelling persons with and without diabetes. Due to common comorbidities and commonly used drugs among persons with diabetes, drug-drug interactions involving warfarin or NSAIDs in particular should be carefully monitored to avoid drug adverse effects.
Subject: adverse effect
diabetes
drug-drug interactions
elderly
POLYPHARMACY
GUIDELINES
PEOPLE
CARE
317 Pharmacy
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