Management of locally recurrent nasopharyngeal carcinoma

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Leea , A W M , Ng , W T , Chan , J Y W , Corry , J , Mäkitie , A , Mendenhall , W M , Rinaldo , A , Rodrigo , J P , Saba , N F , Strojan , P , Suarez , C , Vermorken , J B , Yom , S S & Ferlito , A 2019 , ' Management of locally recurrent nasopharyngeal carcinoma ' , Cancer Treatment Reviews , vol. 79 , 101890 . https://doi.org/10.1016/j.ctrv.2019.101890

Title: Management of locally recurrent nasopharyngeal carcinoma
Author: Leea, Anne W. M.; Ng, Wai Tong; Chan, Jimmy Y. W.; Corry, June; Mäkitie, Antti; Mendenhall, William M.; Rinaldo, Alessandra; Rodrigo, Juan P.; Saba, Nabil F.; Strojan, Primoz; Suarez, Carlos; Vermorken, Jan B.; Yom, Sue S.; Ferlito, Alfio
Contributor: University of Helsinki, HUS Head and Neck Center
Date: 2019-09
Language: eng
Number of pages: 10
Belongs to series: Cancer Treatment Reviews
ISSN: 0305-7372
URI: http://hdl.handle.net/10138/320963
Abstract: As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10-20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the possibility of radio-resistance of tumors which persist or recur despite adequate prior irradiation and the limited tolerance of adjacent normal tissues to sustain further additional treatment, the management of local failures remains one of the greatest challenges in this disease. Both surgical approaches for radical resection and specialized re-irradiation modalities have been explored. Unfortunately, available data are based on retrospective studies, and the majority of them are based on a small number of patients or relatively short follow-up. In this article, we will review the different salvage treatment options and associated prognostic factors for each of them. We will also propose a treatment algorithm based on the latest available evidence and discuss the future directions of treatment for locally recurrent NPC.
Subject: Nasopharyngeal carcinoma
Recurrent
Nasopharyngectomy
Radiotherapy
Prognostic factor
INTENSITY-MODULATED RADIOTHERAPY
BARR-VIRUS DNA
TEMPORAL-LOBE NECROSIS
LONG-TERM OUTCOMES
SALVAGE ENDOSCOPIC NASOPHARYNGECTOMY
STEREOTACTIC BODY RADIOTHERAPY
CAROTID BLOWOUT SYNDROME
RADIATION-THERAPY
PHOTODYNAMIC THERAPY
SURGICAL SALVAGE
3122 Cancers
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