Regulation of nuclear actin dynamics in development and disease

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Hyrskyluoto , A & Vartiainen , M K 2020 , ' Regulation of nuclear actin dynamics in development and disease ' , Current Opinion in Cell Biology , vol. 64 , pp. 18-24 . https://doi.org/10.1016/j.ceb.2020.01.012

Title: Regulation of nuclear actin dynamics in development and disease
Author: Hyrskyluoto, Alise; Vartiainen, Maria K.
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Nuclear organization by actin


Date: 2020-06
Language: eng
Number of pages: 7
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
DOI: https://doi.org/10.1016/j.ceb.2020.01.012
URI: http://hdl.handle.net/10138/321011
Abstract: Actin has essential functions both in the cytoplasm and in the nucleus, where it has been linked to key nuclear processes, from transcription to DNA damage response. The multifunctional nature of actin suggests that the cell must contain mechanisms to accurately control the cellular actin balance. Indeed, recent results have demonstrated that nuclear actin levels fluctuate to regulate the transcriptional activity of the cell and that controlled nuclear actin polymerization is required for transcription activation, cell cycle progression, and DNA repair. Intriguingly, aberrant nuclear actin regulation has been observed, for example, in cancer, signifying the importance of this process for cellular homeostasis. This review discussed the latest research on how nuclear actin is regulated, and how this influences actin-dependent nuclear processes.
Subject: Actin
nuclear actin
transcription
DNA damage response
SRF
Actin
nuclear actin
transcription
DNA damage response
SRF
BETA-ACTIN
F-ACTIN
TRANSCRIPTION
QUIESCENCE
STABILIZES
INITIATION
MOVEMENT
NETWORK
EMERIN
1182 Biochemistry, cell and molecular biology
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