Regulation of nuclear actin dynamics in development and disease
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Hyrskyluoto , A & Vartiainen , M K 2020 , ' Regulation of nuclear actin dynamics in development and disease ' , Current Opinion in Cell Biology , vol. 64 , pp. 18-24 . https://doi.org/10.1016/j.ceb.2020.01.012
| Title: | Regulation of nuclear actin dynamics in development and disease |
| Author: | Hyrskyluoto, Alise; Vartiainen, Maria K. |
| Contributor organization: | Institute of Biotechnology Department of Biochemistry and Developmental Biology Nuclear organization by actin |
| Date: | 2020-06 |
| Language: | eng |
| Number of pages: | 7 |
| Belongs to series: | Current Opinion in Cell Biology |
| ISSN: | 0955-0674 |
| DOI: | https://doi.org/10.1016/j.ceb.2020.01.012 |
| URI: | http://hdl.handle.net/10138/321011 |
| Abstract: | Actin has essential functions both in the cytoplasm and in the nucleus, where it has been linked to key nuclear processes, from transcription to DNA damage response. The multifunctional nature of actin suggests that the cell must contain mechanisms to accurately control the cellular actin balance. Indeed, recent results have demonstrated that nuclear actin levels fluctuate to regulate the transcriptional activity of the cell and that controlled nuclear actin polymerization is required for transcription activation, cell cycle progression, and DNA repair. Intriguingly, aberrant nuclear actin regulation has been observed, for example, in cancer, signifying the importance of this process for cellular homeostasis. This review discussed the latest research on how nuclear actin is regulated, and how this influences actin-dependent nuclear processes. |
| Subject: |
Actin
nuclear actin transcription DNA damage response SRF Actin nuclear actin transcription DNA damage response SRF BETA-ACTIN F-ACTIN TRANSCRIPTION QUIESCENCE STABILIZES INITIATION MOVEMENT NETWORK EMERIN 1182 Biochemistry, cell and molecular biology |
| Peer reviewed: | Yes |
| Rights: | cc_by_nc_nd |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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