Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level : A Critical Discussion

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Gylling , H , Strandberg , T E , Kovanen , P T & Simonen , P 2020 , ' Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level : A Critical Discussion ' , Nutrients , vol. 12 , no. 8 , 2346 . https://doi.org/10.3390/nu12082346

Title: Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level : A Critical Discussion
Author: Gylling, Helena; Strandberg, Timo E.; Kovanen, Petri T.; Simonen, Piia
Contributor: University of Helsinki, Helsinki University Hospital Area
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Wihuri Research Institute
University of Helsinki, Clinicum
Date: 2020-08
Language: eng
Number of pages: 12
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/321013
Abstract: Atherosclerotic cardiovascular diseases (ASCVDs) cause every fifth death worldwide. However, it is possible to prevent the progression of ASCVDs by reducing circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Recent large meta-analyses demonstrated that by reducing the dietary intake of saturated fat and cholesterol, it is possible to reduce the risk of ASCVD events. Plant stanols, as fatty-acid esters, were developed as a dietary adjunct to reduce LDL-C levels as part of a heart-healthy diet. They reduce cholesterol absorption so that less cholesterol is transported to the liver, and the expression of LDL receptors is upregulated. Ultimately, LDL-C concentrations are reduced on average by 9-12% by consuming 2-3 g of plant stanol esters per day. In this review, we discuss recent information regarding the prevention of ASCVDs with a focus on dietary means. We also present new estimates on the effect of plant stanol ester consumption on LDL-C levels and the risk of ASCVD events. Plant stanol esters as part of a heart-healthy diet plausibly offer a means to reduce the risk of ASCVD events at a population level. This approach is not only appropriate for subjects with a high risk of ASCVD, but also for subjects at an apparently lower risk to prevent subclinical atherosclerosis.
Subject: atherosclerosis
cardiovascular disease
cholesterol
lipoprotein
nutrition
plant stanol
risk reduction
DIETARY-CHOLESTEROL
SERUM-CHOLESTEROL
LDL-CHOLESTEROL
000 PARTICIPANTS
STATIN THERAPY
ABSORPTION
METAANALYSIS
METABOLISM
EZETIMIBE
EFFICACY
3143 Nutrition
3121 Internal medicine
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