Improving therapeutic potential of GDNF family ligands

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http://hdl.handle.net/10138/321075

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Runeberg-Roos , P & Penn , R D 2020 , ' Improving therapeutic potential of GDNF family ligands ' , Cell and Tissue Research , vol. 382 , no. 1 , pp. 173-183 . https://doi.org/10.1007/s00441-020-03256-z

Title: Improving therapeutic potential of GDNF family ligands
Author: Runeberg-Roos, Pia; Penn, Richard D.
Contributor: University of Helsinki, University Management
Date: 2020-10
Language: eng
Number of pages: 11
Belongs to series: Cell and Tissue Research
ISSN: 0302-766X
URI: http://hdl.handle.net/10138/321075
Abstract: The last decade has been a frustrating time for investigators who had envisioned major advances in the treatment of Parkinson's disease using neurotrophic factors. The first trials of glial cell line-derived neurotrophic factor for treating Parkinson's disease were very promising. Later blinded control trials were disappointing, not reaching the predetermined outcomes for improvement in motor function. Consideration of the problems in the studies as well as the biology of the neurotrophins used can potentially lead to more effective therapies. Parkinson's disease presents a multitude of opportunities for the cell biologist wanting to understand its pathology and to find possible new avenues for treatment.
Subject: GDNF family ligands
Parkinson's disease
Cell biology
NRTN
CONVECTION-ENHANCED DELIVERY
DEEP BRAIN-STIMULATION
NEUROTROPHIC FACTOR
PARKINSON-DISEASE
HEPARAN-SULFATE
NEURTURIN NTN
RECEPTOR
RET
INFUSION
BINDING
1182 Biochemistry, cell and molecular biology
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