Indoor bacterial microbiota and development of asthma by 10.5 years of age

Show full item record



Karvonen , A M , Kirjavainen , P V , Täubel , M , Jayaprakash , B , Adams , R I , Sordillo , J E , Gold , D R , Hyvärinen , A , Remes , S , von Mutius , E & Pekkanen , J 2019 , ' Indoor bacterial microbiota and development of asthma by 10.5 years of age ' , Journal of Allergy and Clinical Immunology , vol. 144 , no. 5 , pp. 1402-1410 .

Title: Indoor bacterial microbiota and development of asthma by 10.5 years of age
Author: Karvonen, Anne M.; Kirjavainen, Pirkka V.; Täubel, Martin; Jayaprakash, Balamuralikrishna; Adams, Rachel I.; Sordillo, Joanne E.; Gold, Diane R.; Hyvärinen, Anne; Remes, Sami; von Mutius, Erika; Pekkanen, Juha
Contributor organization: Department of Public Health
University of Helsinki
Date: 2019-11
Language: eng
Number of pages: 9
Belongs to series: Journal of Allergy and Clinical Immunology
ISSN: 0091-6749
Abstract: Background: Early-life indoor bacterial exposure is associated with the risk of asthma, but the roles of specific bacterial genera are poorly understood. Objective: We sought to determine whether individual bacterial genera in indoor microbiota predict the development of asthma. Methods: Dust samples from living rooms were collected at 2 months of age. The dust microbiota was characterized by using Illumina MiSeq sequencing amplicons of the bacterial 16S ribosomal RNA gene. Children (n = 373) were followed up for ever asthma until the age of 10.5 years. Results: Richness was inversely associated with asthma after adjustments (P = .03). The phylogenetic microbiota composition in asthmatics patients' homes was characteristically different from that in nonasthmatic subjects' homes (P = .02, weighted UniFrac, adjusted association, permutational multivariate analysis of variance, PERMANOVA-S). The first 2 axis scores of principal coordinate analysis of the weighted UniFrac distance matrix were inversely associated with asthma. Of 658 genera detected in the dust samples, the relative abundances of 41 genera correlated (r > vertical bar 0.4 vertical bar) with one of these axes. Lactococcus genus was a risk factor for asthma (adjusted odds ratio, 1.36 [95% CI, 1.13-1.63] per interquartile range change). The abundance of 12 bacterial genera (mostly from the Actinomycetales order) was associated with lower asthma risk (P <.10), although not independently of each other. The sum relative abundance of these 12 intercorrelated genera was significantly protective and explained the majority of the association of richness with less asthma. Conclusion: Our data confirm that phylogenetic differences in the microbiota of infants' homes are associated with subsequent asthma risk and suggest that communities of selected bacteria are more strongly linked to asthma protection than individual bacterial taxa or mere richness.
Subject: Asthma development
Lactococcus species
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Indoor_Bacteria ... a_by_10.5_years_of_age.pdf 2.466Mb PDF View/Open
1_s2.0_S0091674919310334_main.pdf 1.361Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record