Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children

Show full item record



Permalink

http://hdl.handle.net/10138/321125

Citation

Tenhu , E , Teräsjärvi , J , Cruzeiro , M L , Savonius , O , Rugemalira , E , Roine , I , He , Q & Pelkonen , T 2020 , ' Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children ' , Genes , vol. 11 , no. 9 , 1099 . https://doi.org/10.3390/genes11091099

Title: Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children
Author: Tenhu, Elina; Teräsjärvi, Johanna; Cruzeiro, Manuel Leite; Savonius, Okko; Rugemalira, Emilie; Roine, Irmeli; He, Qiushui; Pelkonen, Tuula
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Helsinki University Hospital Area
Date: 2020-09
Language: eng
Number of pages: 14
Belongs to series: Genes
ISSN: 2073-4425
DOI: https://doi.org/10.3390/genes11091099
URI: http://hdl.handle.net/10138/321125
Abstract: Bacterial meningitis (BM) is a severe disease caused by various bacterial pathogens. Toll-like receptors (TLRs) protect humans from invading pathogens. In this study, we determined whether single nucleotide polymorphisms (SNPs) ofTLR4andTLR9are associated with susceptibility to and outcome of BM in Angolan children. Samples were taken from 241 patients and 265 age-matched ethnic controls. The SNPsTLR4rs4986790 (896A > G) andTLR9rs187084 (-1486T > C) were determined by high-resolution melting analysis (HRMA). The frequency of variant genotypes inTLR4was significantly higher in patients withHaemophilus influenzaemeningitis than controls (odds ratio (OR), 2.5; 95% confidence interval (CI), 1.2-5.4;p= 0.021), whereas the frequency of variant genotypes inTLR9was significantly lower in patients withH. influenzaemeningitis than controls (OR, 0.4; 95% CI, 0.2-0.9;p= 0.036). No such differences were found with other causative pathogens, such asStreptococcus pneumoniaeandNeisseria meningitidis. At the time of discharge, patients with meningitis caused by Gram-negative bacteria who were carriers of variantTLR4genotypes had a higher risk of ataxia (OR, 12.91; 95% CI, 1.52-109.80;p= 0.019) and other neurological sequelae (OR, 11.85; 95% CI, 1.07-131.49;p= 0.044) than those with the wild-typeTLR4genotype. Our study suggests an association betweenH. influenzaemeningitis and genetic variation betweenTLR4andTLR9in Angolan children.
Subject: TLR4
TLR9
gene polymorphisms
meningitis
Haemophilus influenzae
HRMA
children
Angola
TOLL-LIKE RECEPTOR-4
SINGLE NUCLEOTIDE POLYMORPHISMS
CHILDHOOD BACTERIAL-MENINGITIS
HAEMOPHILUS-INFLUENZAE
STREPTOCOCCUS-PNEUMONIAE
CEREBROSPINAL-FLUID
SUSCEPTIBILITY
TOLL-LIKE-RECEPTOR-4
MUTATIONS
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
genes_11_01099.pdf 771.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record