Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines

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Cheng , R , Fontana , F , Xiao , J , Liu , Z , Figueiredo , P , Shahbazi , M-A , Wang , S , Jin , J , Torrieri , G , Hirvonen , J T , Zhang , H , Chen , T , Cui , W , Lu , Y & Santos , H A 2020 , ' Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines ' , ACS Applied Materials & Interfaces , vol. 12 , no. 40 , pp. 44554-44562 . https://doi.org/10.1021/acsami.0c15057

Title: Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines
Author: Cheng, Ruoyu; Fontana, Flavia; Xiao, Junyuan; Liu, Zehua; Figueiredo, Patricia; Shahbazi, Mohammad-Ali; Wang, Shiqi; Jin, Jing; Torrieri, Giulia; Hirvonen, Jouni T.; Zhang, Hongbo; Chen, Tongtong; Cui, Wenguo; Lu, Yong; Santos, Helder A.
Other contributor: University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Åbo Akademi University
University of Helsinki, Helsinki One Health (HOH)







Date: 2020-10-07
Language: eng
Number of pages: 9
Belongs to series: ACS Applied Materials & Interfaces
ISSN: 1944-8244
DOI: https://doi.org/10.1021/acsami.0c15057
URI: http://hdl.handle.net/10138/321126
Abstract: Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as vacosome) by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.
Subject: cancer vaccines
cancer immunotherapy
liposomes
cancer cell membrane
ADJUVANT SYSTEM
LIPOSOMES
MEMORY
IMMUNITY
CELLS
DELIVERY
317 Pharmacy
3122 Cancers
318 Medical biotechnology
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