A large effective population size for established within-host influenza virus infection

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http://hdl.handle.net/10138/321147

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Lumby , C K , Zhao , L , Breuer , J & Illingworth , C J R 2020 , ' A large effective population size for established within-host influenza virus infection ' , eLife , vol. 9 , 56915 . https://doi.org/10.7554/eLife.56915

Titel: A large effective population size for established within-host influenza virus infection
Författare: Lumby, Casper K.; Zhao, Lei; Breuer, Judith; Illingworth, Christopher J. R.
Medarbetare: University of Helsinki, Department of Computer Science
Datum: 2020-08-10
Språk: eng
Sidantal: 17
Tillhör serie: eLife
ISSN: 2050-084X
Permanenta länken (URI): http://hdl.handle.net/10138/321147
Abstrakt: Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the within-host relationship between selection and the stochastic effects of genetic drift, estimating an effective population size of infection N-e for influenza infection. Examining whole-genome sequence data describing a chronic case of influenza B in a severely immunocompromised child we infer an N-e of 2.5 x 10(7) (95% confidence range 1.0 x 10(7) to 9.0 x 10(7)) suggesting that genetic drift is of minimal importance during an established influenza infection. Our result, supported by data from influenza A infection, suggests that positive selection during within-host infection is primarily limited by the typically short period of infection. Atypically long infections may have a disproportionate influence upon global patterns of viral evolution.
Subject: OSELTAMIVIR-RESISTANT
EVOLUTION
DYNAMICS
DIVERSITY
SELECTION
PATTERNS
1181 Ecology, evolutionary biology
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