A large effective population size for established within-host influenza virus infection

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dc.contributor University of Helsinki, Department of Computer Science en
dc.contributor.author Lumby, Casper K.
dc.contributor.author Zhao, Lei
dc.contributor.author Breuer, Judith
dc.contributor.author Illingworth, Christopher J. R.
dc.date.accessioned 2020-11-05T16:23:04Z
dc.date.available 2020-11-05T16:23:04Z
dc.date.issued 2020-08-10
dc.identifier.citation Lumby , C K , Zhao , L , Breuer , J & Illingworth , C J R 2020 , ' A large effective population size for established within-host influenza virus infection ' , eLife , vol. 9 , 56915 . https://doi.org/10.7554/eLife.56915 en
dc.identifier.issn 2050-084X
dc.identifier.other PURE: 150530597
dc.identifier.other PURE UUID: 4eea745b-0588-4890-93d7-408ec96b3329
dc.identifier.other WOS: 000562957200001
dc.identifier.uri http://hdl.handle.net/10138/321147
dc.description.abstract Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the within-host relationship between selection and the stochastic effects of genetic drift, estimating an effective population size of infection N-e for influenza infection. Examining whole-genome sequence data describing a chronic case of influenza B in a severely immunocompromised child we infer an N-e of 2.5 x 10(7) (95% confidence range 1.0 x 10(7) to 9.0 x 10(7)) suggesting that genetic drift is of minimal importance during an established influenza infection. Our result, supported by data from influenza A infection, suggests that positive selection during within-host infection is primarily limited by the typically short period of infection. Atypically long infections may have a disproportionate influence upon global patterns of viral evolution. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof eLife
dc.rights en
dc.subject EVOLUTION en
dc.subject DYNAMICS en
dc.subject DIVERSITY en
dc.subject SELECTION en
dc.subject PATTERNS en
dc.subject 1181 Ecology, evolutionary biology en
dc.title A large effective population size for established within-host influenza virus infection en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.7554/eLife.56915
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion

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