A large effective population size for established within-host influenza virus infection

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dc.contributor University of Helsinki, Department of Computer Science en
dc.contributor.author Lumby, Casper K.
dc.contributor.author Zhao, Lei
dc.contributor.author Breuer, Judith
dc.contributor.author Illingworth, Christopher J. R.
dc.date.accessioned 2020-11-05T16:23:04Z
dc.date.available 2020-11-05T16:23:04Z
dc.date.issued 2020-08-10
dc.identifier.citation Lumby , C K , Zhao , L , Breuer , J & Illingworth , C J R 2020 , ' A large effective population size for established within-host influenza virus infection ' , eLife , vol. 9 , 56915 . https://doi.org/10.7554/eLife.56915 en
dc.identifier.issn 2050-084X
dc.identifier.other PURE: 150530597
dc.identifier.other PURE UUID: 4eea745b-0588-4890-93d7-408ec96b3329
dc.identifier.other WOS: 000562957200001
dc.identifier.uri http://hdl.handle.net/10138/321147
dc.description.abstract Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the within-host relationship between selection and the stochastic effects of genetic drift, estimating an effective population size of infection N-e for influenza infection. Examining whole-genome sequence data describing a chronic case of influenza B in a severely immunocompromised child we infer an N-e of 2.5 x 10(7) (95% confidence range 1.0 x 10(7) to 9.0 x 10(7)) suggesting that genetic drift is of minimal importance during an established influenza infection. Our result, supported by data from influenza A infection, suggests that positive selection during within-host infection is primarily limited by the typically short period of infection. Atypically long infections may have a disproportionate influence upon global patterns of viral evolution. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof eLife
dc.rights en
dc.subject OSELTAMIVIR-RESISTANT en
dc.subject EVOLUTION en
dc.subject DYNAMICS en
dc.subject DIVERSITY en
dc.subject SELECTION en
dc.subject PATTERNS en
dc.subject 1181 Ecology, evolutionary biology en
dc.title A large effective population size for established within-host influenza virus infection en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.7554/eLife.56915
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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