Microfluidics for Production of Particles : Mechanism, Methodology, and Applications

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Liu , Z , Fontana , F , Python , A , Hirvonen , J T & Santos , H A 2020 , ' Microfluidics for Production of Particles : Mechanism, Methodology, and Applications ' , Small , vol. 16 , no. 9 , 1904673 . https://doi.org/10.1002/smll.201904673

Title: Microfluidics for Production of Particles : Mechanism, Methodology, and Applications
Author: Liu, Zehua; Fontana, Flavia; Python, Andre; Hirvonen, Jouni T.; Santos, Helder A.
Other contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Helsinki One Health (HOH)





Date: 2020-03-05
Language: eng
Number of pages: 24
Belongs to series: Small
ISSN: 1613-6810
DOI: https://doi.org/10.1002/smll.201904673
URI: http://hdl.handle.net/10138/321179
Abstract: In the past two decades, microfluidics-based particle production is widely applied for multiple biological usages. Compared to conventional bulk methods, microfluidic-assisted particle production shows significant advantages, such as narrower particle size distribution, higher reproducibility, improved encapsulation efficiency, and enhanced scaling-up potency. Herein, an overview of the recent progress of the microfluidics technology for nano-, microparticles or droplet fabrication, and their biological applications is provided. For both nano-, microparticles/droplets, the previously established mechanisms behind particle production via microfluidics and some typical examples during the past five years are discussed. The emerging interdisciplinary technologies based on microfluidics that have produced microparticles or droplets for cellular analysis and artificial cells fabrication are summarized. The potential drawbacks and future perspectives are also briefly discussed.
Subject: biological analysis
drug delivery
microfluidics
microparticles
nanoparticles
ONE-STEP FABRICATION
ON-A-CHIP
NANOPARTICLE FORMATION
POROUS SILICON
POLYMERIC NANOPARTICLES
DROPLET-MICROFLUIDICS
STAGGERED HERRINGBONE
FLOW CHARACTERISTICS
ARTIFICIAL CELLS
LIPID VESICLES
116 Chemical sciences
221 Nano-technology
317 Pharmacy
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