Clinical Course of Pseudophakic Cystoid Macular Edema Treated with Nepafenac

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Aaronson , A , Achiron , A & Tuuminen , R 2020 , ' Clinical Course of Pseudophakic Cystoid Macular Edema Treated with Nepafenac ' , Journal of clinical medicine , vol. 9 , no. 9 , 3034 . https://doi.org/10.3390/jcm9093034

Title: Clinical Course of Pseudophakic Cystoid Macular Edema Treated with Nepafenac
Author: Aaronson, Alexander; Achiron, Asaf; Tuuminen, Raimo
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, Medicum
Date: 2020-09
Language: eng
Number of pages: 10
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
URI: http://hdl.handle.net/10138/321203
Abstract: Background: To evaluate the clinical course of pseudophakic cystoid macular edema (PCME) treated with topical non-steroidal anti-inflammatory drugs (NSAIDs). Methods: An analysis of the clinical course of PCME consisting of 536 eyes of 536 patients from five consecutive randomized clinical trials aimed at the optimization of anti-inflammatory medication in patients undergoing routine cataract surgery. PCME was classified as (i) grade 0a; no macular thickening, (ii) grade 0b; macular thickening (central subfield macular thickness (CSMT) increase of at least 10%) without signs of macular edema, (iii) grade I; subclinical PCME, (iv) grade II; acute PCME, (v) grade III; long-standing PCME. Eyes with PCME classification from grade I onwards were treated with nepafenac 1 mg/mL t.i.d. for two months. Results: CSMT increase of at least 10% at any postoperative timepoint with cystoid changes-a criterion for PCME-was found in 19 of 536 eyes (total incidence 3.5%). Of these 19 eyes, 13 eyes (total incidence 2.4%) had clinically significant PCME. PCME was considered clinically significant when both of the following visual acuity criteria were fulfilled. At any timepoint after the cataract surgery both the corrected distance visual acuity (CDVA) gain was less than 0.4 decimals from that of preoperative CDVA, and the absolute CDVA level remained below 0.8 decimals. Only one of the 19 eyes with criteria for PCME (total incidence 0.2%, incidence of PCME eyes 5.3%) showed no macular edema resolution within 2 months after topical nepafenac administration.Conclusions:PCME in most cases is self-limiting using topical nepafenac without any further need for intravitreal treatment.
Subject: cataract surgery
consensus criteria
intravitreal injection
non-steroidal anti-inflammatory drug
pseudophakic cystoid macular edema
INTRAVITREAL TRIAMCINOLONE ACETONIDE
EUROPEAN MULTICENTER TRIAL
ANTIINFLAMMATORY EYE DROPS
POST-CATARACT PREVENTION
UNCOMPLICATED PHACOEMULSIFICATION
SURGERY
INFLAMMATION
BEVACIZUMAB
EFFICACY
RETINA
3121 General medicine, internal medicine and other clinical medicine
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