Non-invasive dye dilution method for measuring an atrial septal defect shunt size

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http://hdl.handle.net/10138/321236

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Muroke , V , Jalanko , M , Simonen , P , Holmström , M , Ventilä , M & Sinisalo , J 2020 , ' Non-invasive dye dilution method for measuring an atrial septal defect shunt size ' , Open Heart , vol. 7 , no. 2 , 001313 . https://doi.org/10.1136/openhrt-2020-001313

Title: Non-invasive dye dilution method for measuring an atrial septal defect shunt size
Author: Muroke, Valtteri; Jalanko, Mikko; Simonen, Piia; Holmström, Miia; Ventilä, Markku; Sinisalo, Juha
Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Clinicum
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
Date: 2020
Language: eng
Number of pages: 6
Belongs to series: Open Heart
ISSN: 2053-3624
URI: http://hdl.handle.net/10138/321236
Abstract: Aims Objective of this study was to evaluate the feasibility of the non-invasive dye dilution method to quantify shunt size related to atrial septal defects (ASD). The diagnostic accuracy of shunt size determination in ASD's has been suboptimal with common non-invasive methods. We have previously developed a cost-effective and time-effective non-invasive dye dilution method. In this method, the indocyanine green solution is injected into the antecubital vein and the appearance of the dye is detected with an earpiece densitometer. Methods and results We studied 192 patients with an ASD. Mean pulmonary blood flow/systemic blood flow (Qp/Qs) was measured with dye dilution technique and compared with following methods: Fick's invasive oximetry (n=49), transoesophageal echocardiography (TEE) measuring ASD size (n=143) and cardiac MR (CMR) (n=9). For the first 49 patients, Qp/Qs was 2.05 +/- 0.70 with the Fick's invasive oximetry and 2.12 +/- 0.68 with dye dilution method with an excellent correlation between the two methods (R=0.902, p Conclusion The dye dilution method with earpiece densitometer recording is a clinically feasible and reliable method to assess shunt size in ASDs.
Subject: congenital heart disease
stroke
MRI
transoesophageal
minimally invasive
TO-RIGHT SHUNT
CONGENITAL HEART-DISEASE
RADIONUCLIDE ANGIOCARDIOGRAPHY
QUANTIFICATION
OXIMETRY
MANAGEMENT
DIAGNOSIS
ACCURACY
DOPPLER
CURVES
3121 General medicine, internal medicine and other clinical medicine
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