Prostate cancer risk prediction using a polygenic risk score

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Sipeky , C , Talala , K M , Tammela , T L J , Taari , K , Auvinen , A & Schleutker , J 2020 , ' Prostate cancer risk prediction using a polygenic risk score ' , Scientific Reports , vol. 10 , no. 1 , 17075 . https://doi.org/10.1038/s41598-020-74172-z

Title: Prostate cancer risk prediction using a polygenic risk score
Author: Sipeky, Csilla; Talala, Kirsi M.; Tammela, Teuvo L. J.; Taari, Kimmo; Auvinen, Anssi; Schleutker, Johanna
Contributor: University of Helsinki, HUS Abdominal Center
Date: 2020-10-13
Language: eng
Number of pages: 7
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/321578
Abstract: Hereditary factors have a strong influence on prostate cancer (PC) risk and poorer outcomes, thus stratification by genetic factors addresses a critical need for targeted PC screening and risk-adapted follow-up. In this Finnish population-based retrospective study 2283 clinically diagnosed and 455 screen-detected patients from the Finnish Randomised Study of Screening for Prostate Cancer (FinRSPC), 2400 healthy individuals have been involved. Individual genetic risk through establishment of a polygenic risk score based on 55 PC risk SNPs identified through the Finnish subset of the Collaborative Oncological Gene-Environment Study was assessed. Men with PC had significantly higher median polygenic risk score compared to the controls (6.59 vs. 3.83, P4 ng/mL in polygenic risk score quartile four compared to quartile one (18.7% vs 8.3%, P
Subject: SUSCEPTIBILITY
MORTALITY
HERITABILITY
ASSOCIATION
VARIANTS
BREAST
3126 Surgery, anesthesiology, intensive care, radiology
3122 Cancers
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