Cohort profile : a nationwide population-based retrospective assessment of oesophageal cancer in the Finnish National Esophago-Gastric Cancer Cohort (FINEGO)

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dc.contributor.author Söderström, Henna K.
dc.contributor.author Rasanen, Jari
dc.contributor.author Saarnio, Juha
dc.contributor.author Toikkanen, Vesa
dc.contributor.author Tyrväinen, Tuula
dc.contributor.author Rantanen, Tuomo
dc.contributor.author Valtola, Antti
dc.contributor.author Ohtonen, Pasi
dc.contributor.author Pääaho, Minna
dc.contributor.author Kokkola, Arto
dc.contributor.author Kallio, Raija
dc.contributor.author Karttunen, Tuomo J.
dc.contributor.author Pohjanen, Vesa-Matti
dc.contributor.author Ristimäki, Ari
dc.contributor.author Laine, Simo
dc.contributor.author Sihvo, Eero
dc.contributor.author Kauppila, Joonas H.
dc.date.accessioned 2020-11-17T13:44:01Z
dc.date.available 2020-11-17T13:44:01Z
dc.date.issued 2020
dc.identifier.citation Söderström , H K , Rasanen , J , Saarnio , J , Toikkanen , V , Tyrväinen , T , Rantanen , T , Valtola , A , Ohtonen , P , Pääaho , M , Kokkola , A , Kallio , R , Karttunen , T J , Pohjanen , V-M , Ristimäki , A , Laine , S , Sihvo , E & Kauppila , J H 2020 , ' Cohort profile : a nationwide population-based retrospective assessment of oesophageal cancer in the Finnish National Esophago-Gastric Cancer Cohort (FINEGO) ' , BMJ Open , vol. 10 , no. 10 , 039575 . https://doi.org/10.1136/bmjopen-2020-039575
dc.identifier.other PURE: 151318376
dc.identifier.other PURE UUID: f533c36b-a33c-459f-a1e1-cc20b7c98c32
dc.identifier.other WOS: 000582257000004
dc.identifier.uri http://hdl.handle.net/10138/321593
dc.description.abstract Purpose The Finnish National Esophago-Gastric Cancer Cohort (FINEGO) was established to combine the available registry data with detailed patient information to form a comprehensive, retrospective, population-based research platform of surgically treated oesophageal and gastric cancer in Finland. This cohort profile describes the 2045 surgically treated patients with oesophageal cancer included in the FINEGO cohort. Participants Registry data were collected from the National Cancer, Patient, Education and Death Registries from 1 January 1987 to 31 December 2016. All patients over 18 years of age, who had either curative surgery, palliative surgery or salvage surgery for primary cancer in the oesophagus are included in this study. Findings to date 2045 patients had surgery for oesophageal cancer in the selected time period. 67.2% were man, and the majority had only minor comorbidities. The proportions of adenocarcinomas and squamous cell carcinomas were 43.1% and 44.4%, respectively, and 12.5% had other or missing histology. Only about 23% of patients received neoadjuvant therapy. Oesophagectomy was the treatment of choice and most patients were treated at low-volume centres, but median annual hospital volume increased over time. Median overall survival was 23 months, 5-year survival for all patients in the cohort was 32.9% and cancer-specific survival was 36.5%. Future plans Even though Finland only has a population of 5.5 million, surgery for oesophageal carcinoma has not been centralised and therefore previously reported results have mostly been small, single-centre cohorts. Because of FINEGO, we now have a population-based, unselected cohort of surgically treated patients, enabling research on national trends over time regarding oesophageal cancer, including patient characteristics, tumour histology, stage and neoadjuvant treatment, surgical techniques, hospital volumes and patient mortality. Data collection is ongoing, and the cohort will be expanded to include more detailed data from patient records and national biobanks. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof BMJ Open
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject gastrointestinal tumours
dc.subject oesophageal disease
dc.subject surgery
dc.subject epidemiology
dc.subject SURVIVAL
dc.subject CHEMORADIOTHERAPY
dc.subject ADENOCARCINOMA
dc.subject RESECTION
dc.subject VOLUME
dc.subject TRENDS
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3122 Cancers
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Cohort profile : a nationwide population-based retrospective assessment of oesophageal cancer in the Finnish National Esophago-Gastric Cancer Cohort (FINEGO) en
dc.type Article
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization III kirurgian klinikka
dc.contributor.organization Doctoral Programme in Clinical Research
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization II kirurgian klinikka
dc.contributor.organization Department of Pathology
dc.contributor.organization HUSLAB
dc.contributor.organization Clinicum
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization ATG - Applied Tumor Genomics
dc.contributor.organization Research Programs Unit
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1136/bmjopen-2020-039575
dc.relation.issn 2044-6055
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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