Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample

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Korhonen , T , Loukola , A , Hällfors , J , Salomaa , M-M , Salomaa , V & Kaprio , J 2020 , ' Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample ' , Nicotine & Tobacco Research , vol. 22 , no. 2 , pp. 293-296 . https://doi.org/10.1093/ntr/nty218

Title: Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample
Author: Korhonen, Tellervo; Loukola, Anu; Hällfors, Jenni; Salomaa, Minna-Maija; Salomaa, Veikko; Kaprio, Jaakko
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Operations Management Unit
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2020-02-06
Language: eng
Number of pages: 4
Belongs to series: Nicotine & Tobacco Research
ISSN: 1462-2203
URI: http://hdl.handle.net/10138/321651
Abstract: Introduction: Brain-derived neurotrophic factor (BDNF) is a growth factor in the central nervous system. There is evidence for the involvement of BDNF in addictions and mental disorders. We aimed to replicate the earlier reported association of a functional genetic variant of BDNF with smoking initiation (SI) using a large population-based sample and to test whether the association is independent of depression. Methods: Our sample was drawn from the Finnish population-based FINRISK surveys conducted in 1992, 1997, 2002, and 2007. We had nonmissing data on the genotype BDNF Val66Met (G/A) variant (rs6265) and self-reported never (n = 10 619) versus ever (n = 16 028) smoking among 26 647 adults aged 25-74 years. The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. Depression was defined as self-reported depression diagnosed or treated by physician during the past year. Results:The sex- and age-adjusted analysis confirmed that the major (Val) allele increased the risk of being a lifetime ever smoker (per allele odds ratio [OR] = 1.07; 95% CI = 1.01 to 1.12; p =.01). When depression, which itself was significantly associated with SI (OR = 1.58; 95% CI = 1.37 to 1.82; p Conclusions: In a Finnish population sample, we replicated the earlier reported association of BDNF Val66Met with SI. Our data further suggest that this association is independent of depression.
Subject: 3142 Public health care science, environmental and occupational health
FACTOR BDNF
DEPRESSION
BEHAVIOR
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