Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample

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dc.contributor.author Korhonen, Tellervo
dc.contributor.author Loukola, Anu
dc.contributor.author Hällfors, Jenni
dc.contributor.author Salomaa, Minna-Maija
dc.contributor.author Salomaa, Veikko
dc.contributor.author Kaprio, Jaakko
dc.date.accessioned 2020-11-18T12:58:07Z
dc.date.available 2020-11-18T12:58:07Z
dc.date.issued 2020-02-06
dc.identifier.citation Korhonen , T , Loukola , A , Hällfors , J , Salomaa , M-M , Salomaa , V & Kaprio , J 2020 , ' Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample ' , Nicotine & Tobacco Research , vol. 22 , no. 2 , pp. 293-296 . https://doi.org/10.1093/ntr/nty218
dc.identifier.other PURE: 130569218
dc.identifier.other PURE UUID: 890b1a7c-2147-4a2d-aebc-47093d5b12af
dc.identifier.other ORCID: /0000-0003-0542-5967/work/70947548
dc.identifier.other WOS: 000546958300020
dc.identifier.uri http://hdl.handle.net/10138/321651
dc.description.abstract Introduction: Brain-derived neurotrophic factor (BDNF) is a growth factor in the central nervous system. There is evidence for the involvement of BDNF in addictions and mental disorders. We aimed to replicate the earlier reported association of a functional genetic variant of BDNF with smoking initiation (SI) using a large population-based sample and to test whether the association is independent of depression. Methods: Our sample was drawn from the Finnish population-based FINRISK surveys conducted in 1992, 1997, 2002, and 2007. We had nonmissing data on the genotype BDNF Val66Met (G/A) variant (rs6265) and self-reported never (n = 10 619) versus ever (n = 16 028) smoking among 26 647 adults aged 25-74 years. The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. Depression was defined as self-reported depression diagnosed or treated by physician during the past year. Results:The sex- and age-adjusted analysis confirmed that the major (Val) allele increased the risk of being a lifetime ever smoker (per allele odds ratio [OR] = 1.07; 95% CI = 1.01 to 1.12; p =.01). When depression, which itself was significantly associated with SI (OR = 1.58; 95% CI = 1.37 to 1.82; p Conclusions: In a Finnish population sample, we replicated the earlier reported association of BDNF Val66Met with SI. Our data further suggest that this association is independent of depression. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof Nicotine & Tobacco Research
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3142 Public health care science, environmental and occupational health
dc.subject FACTOR BDNF
dc.subject DEPRESSION
dc.subject BEHAVIOR
dc.title Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample : Replication Using a Large Finnish Population Sample en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.contributor.organization HUSLAB
dc.contributor.organization Operations Management Unit
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/ntr/nty218
dc.relation.issn 1462-2203
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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