Inductive signals in branching morphogenesis - lessons from mammary and salivary glands

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http://hdl.handle.net/10138/321708

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Myllymaki , S-M & Mikkola , M L 2019 , ' Inductive signals in branching morphogenesis - lessons from mammary and salivary glands ' , Current Opinion in Cell Biology , vol. 61 , pp. 72-78 . https://doi.org/10.1016/j.ceb.2019.07.001

Title: Inductive signals in branching morphogenesis - lessons from mammary and salivary glands
Author: Myllymaki, Satu-Marja; Mikkola, Marja L.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Marja Mikkola / Principal Investigator
Date: 2019-12
Language: eng
Number of pages: 7
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
URI: http://hdl.handle.net/10138/321708
Abstract: Branching morphogenesis is a fundamental developmental program that generates large epithelial surfaces in a limited three-dimensional space. It is regulated by inductive tissue interactions whose effects are mediated by soluble signaling molecules, and cell-cell and cell-extracellular matrix interactions. Here, we will review recent studies on inductive signaling interactions governing branching morphogenesis in light of phenotypes of mouse mutants and ex vivo organ culture studies with emphasis on developing mammary and salivary glands. We will highlight advances in understanding how cell fate decisions are intimately linked with branching morphogenesis. We will also discuss novel insights into the molecular control of cellular mechanisms driving the formation of these arborized ductal structures and reflect upon how distinct spatial patterns are generated.
Subject: EPITHELIAL-CELL DYNAMICS
STEM-CELLS
GROWTH
ECTODYSPLASIN
MECHANISMS
POLARITY
BUD
1182 Biochemistry, cell and molecular biology
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