Inductive signals in branching morphogenesis - lessons from mammary and salivary glands

Visa fullständig post



Permalänk

http://hdl.handle.net/10138/321708

Citation

Myllymaki , S-M & Mikkola , M L 2019 , ' Inductive signals in branching morphogenesis - lessons from mammary and salivary glands ' , Current Opinion in Cell Biology , vol. 61 , pp. 72-78 . https://doi.org/10.1016/j.ceb.2019.07.001

Titel: Inductive signals in branching morphogenesis - lessons from mammary and salivary glands
Författare: Myllymaki, Satu-Marja; Mikkola, Marja L.
Medarbetare: University of Helsinki, Institute of Biotechnology
University of Helsinki, Marja Mikkola / Principal Investigator
Datum: 2019-12
Språk: eng
Sidantal: 7
Tillhör serie: Current Opinion in Cell Biology
ISSN: 0955-0674
Permanenta länken (URI): http://hdl.handle.net/10138/321708
Abstrakt: Branching morphogenesis is a fundamental developmental program that generates large epithelial surfaces in a limited three-dimensional space. It is regulated by inductive tissue interactions whose effects are mediated by soluble signaling molecules, and cell-cell and cell-extracellular matrix interactions. Here, we will review recent studies on inductive signaling interactions governing branching morphogenesis in light of phenotypes of mouse mutants and ex vivo organ culture studies with emphasis on developing mammary and salivary glands. We will highlight advances in understanding how cell fate decisions are intimately linked with branching morphogenesis. We will also discuss novel insights into the molecular control of cellular mechanisms driving the formation of these arborized ductal structures and reflect upon how distinct spatial patterns are generated.
Subject: EPITHELIAL-CELL DYNAMICS
STEM-CELLS
GROWTH
ECTODYSPLASIN
MECHANISMS
POLARITY
BUD
1182 Biochemistry, cell and molecular biology
Licens:


Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
COCEBI_2019_12_Revision_1_V0_for_TUHAT.pdf 1.734Mb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post