Inductive signals in branching morphogenesis - lessons from mammary and salivary glands

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dc.contributor University of Helsinki, Institute of Biotechnology en
dc.contributor University of Helsinki, Marja Mikkola / Principal Investigator en
dc.contributor.author Myllymaki, Satu-Marja
dc.contributor.author Mikkola, Marja L.
dc.date.accessioned 2020-11-19T11:58:01Z
dc.date.available 2020-11-19T11:58:01Z
dc.date.issued 2019-12
dc.identifier.citation Myllymaki , S-M & Mikkola , M L 2019 , ' Inductive signals in branching morphogenesis - lessons from mammary and salivary glands ' , Current Opinion in Cell Biology , vol. 61 , pp. 72-78 . https://doi.org/10.1016/j.ceb.2019.07.001 en
dc.identifier.issn 0955-0674
dc.identifier.other PURE: 131597750
dc.identifier.other PURE UUID: a1823b9f-dfb6-4f21-bc03-e9a561ec5641
dc.identifier.other WOS: 000501828200011
dc.identifier.other ORCID: /0000-0003-0521-5062/work/85521586
dc.identifier.uri http://hdl.handle.net/10138/321708
dc.description.abstract Branching morphogenesis is a fundamental developmental program that generates large epithelial surfaces in a limited three-dimensional space. It is regulated by inductive tissue interactions whose effects are mediated by soluble signaling molecules, and cell-cell and cell-extracellular matrix interactions. Here, we will review recent studies on inductive signaling interactions governing branching morphogenesis in light of phenotypes of mouse mutants and ex vivo organ culture studies with emphasis on developing mammary and salivary glands. We will highlight advances in understanding how cell fate decisions are intimately linked with branching morphogenesis. We will also discuss novel insights into the molecular control of cellular mechanisms driving the formation of these arborized ductal structures and reflect upon how distinct spatial patterns are generated. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Current Opinion in Cell Biology
dc.rights en
dc.subject EPITHELIAL-CELL DYNAMICS en
dc.subject STEM-CELLS en
dc.subject GROWTH en
dc.subject ECTODYSPLASIN en
dc.subject MECHANISMS en
dc.subject POLARITY en
dc.subject BUD en
dc.subject 1182 Biochemistry, cell and molecular biology en
dc.title Inductive signals in branching morphogenesis - lessons from mammary and salivary glands en
dc.type Review Article
dc.identifier.doi https://doi.org/10.1016/j.ceb.2019.07.001
dc.type.uri info:eu-repo/semantics/other
dc.contributor.pbl
dc.contributor.pbl

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