Co-circulation of highly diverse Aleutian mink disease virus strains in Finland

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http://hdl.handle.net/10138/321861

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Virtanen , J , Smura , T , Aaltonen , K , Moisander-Jylhä , A-M , Knuuttila , A , Vapalahti , O & Sironen , T 2019 , ' Co-circulation of highly diverse Aleutian mink disease virus strains in Finland ' , Journal of General Virology , vol. 100 , no. 2 , pp. 227-236 . https://doi.org/10.1099/jgv.0.001187

Title: Co-circulation of highly diverse Aleutian mink disease virus strains in Finland
Author: Virtanen, Jenni; Smura, Teemu; Aaltonen, Kirsi; Moisander-Jylhä, Anna-Maria; Knuuttila, Anna; Vapalahti, Olli; Sironen, Tarja
Other contributor: University of Helsinki, Veterinary Biosciences
University of Helsinki, HUSLAB
University of Helsinki, Veterinary Microbiology and Epidemiology
University of Helsinki, Veterinary Biosciences
University of Helsinki, Veterinary Biosciences
University of Helsinki, Veterinary Microbiology and Epidemiology
University of Helsinki, Viral Zoonosis Research Unit










Date: 2019-02
Language: eng
Number of pages: 10
Belongs to series: Journal of General Virology
ISSN: 0022-1317
DOI: https://doi.org/10.1099/jgv.0.001187
URI: http://hdl.handle.net/10138/321861
Abstract: Aleutian mink disease virus (AMDV) is the causative agent of Aleutian disease (AD), which affects mink of all genotypes and also infects other mustelids such as ferrets, martens and badgers. Previous studies have investigated diversity in Finnish AMDV strains, but these studies have been restricted to small parts of the virus genome, and mostly from newly infected farms and free-ranging mustelids. Here, we investigated the diversity and evolution of Finnish AMDV strains by sequencing the complete coding sequences of 31 strains from mink originating from farms differing in their virus history, as well as from free-ranging mink. The data set was supplemented with partial genomes obtained from 26 strains. The sequences demonstrate that the Finnish AMDV strains have considerable diversity, and that the virus has been introduced to Finland in multiple events. Frequent recombination events were observed, as well as variation in the evolutionary rate in different parts of the genome and between different branches of the phylogenetic tree. Mink in the wild carry viruses with high intra-host diversity and are occasionally even co-infected by two different strains, suggesting that free-ranging mink tolerate chronic infections for extended periods of time. These findings highlight the need for further sampling to understand the mechanisms playing a role in the evolution and pathogenesis of AMDV.
Subject: AMDV
NGS
phylogeny
molecular epidemiology
NUCLEOTIDE-SEQUENCE
ANALYSIS REVEALS
MOSAIC STRUCTURE
READ ALIGNMENT
WHOLE-GENOME
PARVOVIRUS
RECOMBINATION
EMERGENCE
EVOLUTION
TYPE-1
1183 Plant biology, microbiology, virology
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