Virtanen , J , Smura , T , Aaltonen , K , Moisander-Jylhä , A-M , Knuuttila , A , Vapalahti , O & Sironen , T 2019 , ' Co-circulation of highly diverse Aleutian mink disease virus strains in Finland ' , Journal of General Virology , vol. 100 , no. 2 , pp. 227-236 . https://doi.org/10.1099/jgv.0.001187
Title: | Co-circulation of highly diverse Aleutian mink disease virus strains in Finland |
Author: | Virtanen, Jenni; Smura, Teemu; Aaltonen, Kirsi; Moisander-Jylhä, Anna-Maria; Knuuttila, Anna; Vapalahti, Olli; Sironen, Tarja |
Contributor organization: | Veterinary Biosciences Viral Zoonosis Research Unit Faculty of Veterinary Medicine HUSLAB Department of Virology Faculty of Medicine Medicum Veterinary Microbiology and Epidemiology Emerging Infections Research Group Olli Pekka Vapalahti / Principal Investigator Helsinki One Health (HOH) |
Date: | 2019-02 |
Language: | eng |
Number of pages: | 10 |
Belongs to series: | Journal of General Virology |
ISSN: | 0022-1317 |
DOI: | https://doi.org/10.1099/jgv.0.001187 |
URI: | http://hdl.handle.net/10138/321861 |
Abstract: | Aleutian mink disease virus (AMDV) is the causative agent of Aleutian disease (AD), which affects mink of all genotypes and also infects other mustelids such as ferrets, martens and badgers. Previous studies have investigated diversity in Finnish AMDV strains, but these studies have been restricted to small parts of the virus genome, and mostly from newly infected farms and free-ranging mustelids. Here, we investigated the diversity and evolution of Finnish AMDV strains by sequencing the complete coding sequences of 31 strains from mink originating from farms differing in their virus history, as well as from free-ranging mink. The data set was supplemented with partial genomes obtained from 26 strains. The sequences demonstrate that the Finnish AMDV strains have considerable diversity, and that the virus has been introduced to Finland in multiple events. Frequent recombination events were observed, as well as variation in the evolutionary rate in different parts of the genome and between different branches of the phylogenetic tree. Mink in the wild carry viruses with high intra-host diversity and are occasionally even co-infected by two different strains, suggesting that free-ranging mink tolerate chronic infections for extended periods of time. These findings highlight the need for further sampling to understand the mechanisms playing a role in the evolution and pathogenesis of AMDV. |
Subject: |
AMDV
NGS phylogeny molecular epidemiology NUCLEOTIDE-SEQUENCE ANALYSIS REVEALS MOSAIC STRUCTURE READ ALIGNMENT WHOLE-GENOME PARVOVIRUS RECOMBINATION EMERGENCE EVOLUTION TYPE-1 1183 Plant biology, microbiology, virology |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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