Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network

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Demetri , G D , Antonescu , C R , Bjerkehagen , B , Bovee , J V M G , Boye , K , Chacon , M , Dei Tos , A P , Desai , J , Fletcher , J A , Gelderblom , H , George , S , Gronchi , A , Haas , R L , Hindi , N , Hohenberger , P , Joensuu , H , Jones , R L , Judson , I , Kang , Y-K , Kawai , A , Lazar , A J , Le Cesne , A , Maestro , R , Maki , R , Martin , J , Patel , S , Penault-Llorca , F , Raut , C P , Rutkowski , P , Safwat , A , Sbaraglia , M , Schaefer , I-M , Shen , L , Serrano , C , Schoffski , P , Stacchiotti , S , Hall , K S , Tap , W D , Thomas , D M , Trent , J , Valverde , C , van der Graaf , W T A , von Mehren , M , Wagner , A , Wardelmann , E , Naito , Y , Zalcberg , J & Blay , J-Y 2020 , ' Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network ' , Annals of Oncology , vol. 31 , no. 11 , pp. 1506-1517 . https://doi.org/10.1016/j.annonc.2020.08.2232

Title: Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network
Author: Demetri, G. D.; Antonescu, C. R.; Bjerkehagen, B.; Bovee, J. V. M. G.; Boye, K.; Chacon, M.; Dei Tos, A. P.; Desai, J.; Fletcher, J. A.; Gelderblom, H.; George, S.; Gronchi, A.; Haas, R. L.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R. L.; Judson, Ian; Kang, Y-K; Kawai, A.; Lazar, A. J.; Le Cesne, A.; Maestro, R.; Maki, Rg; Martin, J.; Patel, S.; Penault-Llorca, F.; Raut, C. Premanand; Rutkowski, P.; Safwat, A.; Sbaraglia, M.; Schaefer, I-M; Shen, L.; Serrano, C.; Schoffski, P.; Stacchiotti, S.; Hall, K. Sundby; Tap, W. D.; Thomas, D. M.; Trent, J.; Valverde, C.; van der Graaf, W. T. A.; von Mehren, M.; Wagner, A.; Wardelmann, E.; Naito, Y.; Zalcberg, J.; Blay, J-Y
Contributor: University of Helsinki, Research Programs Unit
Date: 2020-11
Language: eng
Number of pages: 12
Belongs to series: Annals of Oncology
ISSN: 0923-7534
URI: http://hdl.handle.net/10138/321873
Abstract: Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions.
Subject: entrectinib
larotrectinib
neurotrophic tyrosine receptor kinase
sarcoma
tropomyosin receptor kinase
GASTROINTESTINAL STROMAL TUMORS
ETV6-NTRK3 GENE FUSION
POSITIVE SOLID TUMORS
NTRK FUSION
CONGENITAL INSENSITIVITY
GROWTH-FACTOR
LAROTRECTINIB
MUTATIONS
CANCERS
SUBSET
3122 Cancers
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