Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

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Early Growth Genetics Consortium , Vogelezang , S , Bradfield , J P , Ahluwalia , T S , Eriksson , J G , Leinonen , J T & Widen , E 2020 , ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ' , PLoS Genetics , vol. 16 , no. 10 , 1008718 . https://doi.org/10.1371/journal.pgen.1008718

Title: Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Author: Early Growth Genetics Consortium; Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Eriksson, Johan G.; Leinonen, Jaakko T.; Widen, Elisabeth
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Genomics of Sex Differences
University of Helsinki, Centre of Excellence in Complex Disease Genetics









Date: 2020-10
Language: eng
Number of pages: 26
Belongs to series: PLoS Genetics
ISSN: 1553-7404
DOI: https://doi.org/10.1371/journal.pgen.1008718
URI: http://hdl.handle.net/10138/321876
Abstract: The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R(g)ranging from 0.11 to 0.76, P-values Author summary Although twin studies have shown that body mass index (BMI) is highly heritable, many common genetic variants involved in the development of BMI have not yet been identified, especially in children. We studied associations of more than 40 million genetic variants with childhood BMI in 61,111 children aged between 2 and 10 years. We identified 25 genetic variants that were associated with childhood BMI. Two of these have not been implicated for BMI previously, located close to the genesNEDD4LandSLC45A3. We also show that the genetic background of childhood BMI overlaps with that of birth weight, adult BMI, waist-to-hip-ratio, diastolic blood pressure, type 2 diabetes, and age at menarche. Our results suggest that the biological processes underlying childhood BMI largely overlap with those underlying adult BMI. However, the overlap is not complete. Additionally, the genetic backgrounds of childhood BMI and other cardio-metabolic phenotypes are overlapping. This may mean that the associations of childhood BMI and later cardio-metabolic outcomes are partially explained by shared genetics, but it could also be explained by the strong association of childhood BMI with adult BMI.
Subject: PROSTATE-SPECIFIC ANTIGEN
GENOME-WIDE ASSOCIATION
MENDELIAN RANDOMIZATION
CARDIOVASCULAR RISK
GENETIC-VARIATION
POOLED ANALYSIS
YOUNG-ADULTS
OBESITY
OVERWEIGHT
ADIPOSITY
1184 Genetics, developmental biology, physiology
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