Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach

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Kwon , H N , Lee , H , Park , J W , Kim , Y-H , Park , S & Kim , J J 2020 , ' Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach ' , Cancers , vol. 12 , no. 10 , 2904 . https://doi.org/10.3390/cancers12102904

Title: Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach
Author: Kwon, Hyuk Nam; Lee, Hyuk; Park, Ji Won; Kim, Young-Ho; Park, Sunghyouk; Kim, Jae J.
Contributor organization: Helsinki Institute of Life Science HiLIFE
Kidney development
STEMM - Stem Cells and Metabolism Research Program
Faculty of Medicine
University of Helsinki
Date: 2020-10-09
Language: eng
Number of pages: 16
Belongs to series: Cancers
ISSN: 2072-6694
DOI: https://doi.org/10.3390/cancers12102904
URI: http://hdl.handle.net/10138/321935
Abstract: The early detection of gastric cancer (GC) could decrease its incidence and mortality. However, there are currently no accurate noninvasive markers for GC screening. Therefore, we developed a noninvasive diagnostic approach, employing urine nuclear magnetic resonance (NMR) metabolomics, to discover putative metabolic markers associated with GC. Changes in urine metabolite levels during oncogenesis were evaluated using samples from 103 patients with GC and 100 age- and sex-matched healthy controls. Approximately 70% of the patients with GC (n = 69) had stage I GC, with the majority (n = 56) having intramucosal cancer. A multivariate statistical analysis of the urine NMR data well discriminated between the patient and control groups and revealed nine metabolites, including alanine, citrate, creatine, creatinine, glycerol, hippurate, phenylalanine, taurine, and 3-hydroxybutyrate, that contributed to the difference. A diagnostic performance test with a separate validation set exhibited a sensitivity and specificity of more than 90%, even with the intramucosal cancer samples only. In conclusion, the NMR-based urine metabolomics approach may have potential as a convenient screening method for the early detection of GC and may facilitate consequent endoscopic examination through risk stratification.
Subject: BIOMARKERS
CA 72-4
CARCINOEMBRYONIC ANTIGEN
CEA
CREATININE
EARLY-DIAGNOSIS
ENDOSCOPY
EXPRESSION
MANAGEMENT
SPECTROMETRY
gastric cancer
metabolomics
screening
urine
3122 Cancers
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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