Impaired glucose regulation, depressive symptoms, and health-related quality of life

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http://hdl.handle.net/10138/321973

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Selenius , J S , Wasenius , N S , Kautiainen , H , Salonen , M , von Bonsdorff , M & Eriksson , J G 2020 , ' Impaired glucose regulation, depressive symptoms, and health-related quality of life ' , BMJ Open Diabetes Research & Care , vol. 8 , no. 1 , 001568 . https://doi.org/10.1136/bmjdrc-2020-001568

Title: Impaired glucose regulation, depressive symptoms, and health-related quality of life
Author: Selenius, Jannica S.; Wasenius, Niko S.; Kautiainen, Hannu; Salonen, Minna; von Bonsdorff, Mikaela; Eriksson, Johan G.
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2020
Language: eng
Number of pages: 8
Belongs to series: BMJ Open Diabetes Research & Care
ISSN: 2052-4897
URI: http://hdl.handle.net/10138/321973
Abstract: Introduction This study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms. Research design and methods For this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. The Mental and Physical Component Scores of health-related quality of life were assessed with Short Form-36. Beck's Depression Inventory was employed to investigate the severity of depressive symptoms and to define minimal (depression score Results Glucose regulation subgroups, especially previously known diabetes, were associated with lower Physical Component Score (p=0.001) and higher depression score (p=0.015), but not with the Mental Component Score (p=0.189). Non-melancholic depression was associated with lower Physical and Mental Component Scores compared with those with depression score 0.54). Conclusions Non-melancholic type of depression and previously known diabetes are independently associated with lower health-related quality of life. This should be appraised in long-term treatment of diabetes and when treating non-melancholic depressive symptoms to maintain a higher health-related quality of life.
Subject: METABOLIC SYNDROME
DIABETES-MELLITUS
PSYCHOMETRIC PROPERTIES
INVENTORY-II
POPULATION
PREVALENCE
RISK
COMPLICATIONS
ASSOCIATION
3121 General medicine, internal medicine and other clinical medicine
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