The relationship between serum 25-hydroxyvitamin D and parathyroid hormone concentration in assessing vitamin D deficiency in pet rabbits

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http://hdl.handle.net/10138/321996

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Makitaipale , J , Sankari , S , Sievänen , H & Laitinen-Vapaavuori , O 2020 , ' The relationship between serum 25-hydroxyvitamin D and parathyroid hormone concentration in assessing vitamin D deficiency in pet rabbits ' , BMC Veterinary Research , vol. 16 , no. 1 , 403 . https://doi.org/10.1186/s12917-020-02599-7

Title: The relationship between serum 25-hydroxyvitamin D and parathyroid hormone concentration in assessing vitamin D deficiency in pet rabbits
Author: Makitaipale, J.; Sankari, S.; Sievänen, H.; Laitinen-Vapaavuori, O.
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, University Management
University of Helsinki, Equine and Small Animal Medicine
Date: 2020-10-27
Language: eng
Number of pages: 8
Belongs to series: BMC Veterinary Research
ISSN: 1746-6148
URI: http://hdl.handle.net/10138/321996
Abstract: Background Vitamin D deficiency and related metabolic bone diseases in pet rabbits have been intermittently debated. In human research, the parathyroid hormone concentration in relation to the 25-hydroxyvitamin D concentration is used to determine vitamin D deficiency. Thus, this study aimed to identify the breakpoint in the 25-hydroxyvitamin D concentration indicating a significant change in the parathyroid hormone concentration in 139 pet rabbits. An enzyme immunoassay kit was used for 25-hydroxyvitamin D analysis and the intact parathyroid hormone (PTH 1-84) immunoradiometric assay kit for parathyroid hormone analysis. The mid-tibial cortical bone density was measured using peripheral quantitative computed tomography. A segmented linear regression analysis was performed, with the 25-hydroxyvitamin D concentration as the independent variable, and parathyroid hormone, ionised calcium, total calcium, inorganic phosphorus concentrations and the mid-tibial cortical density as the dependent variables. Results The breakpoint for the parathyroid hormone concentration occurred at a 25(OH)D concentration of 17 ng/mL, whereas the cortical bone density breakpoint occurred at a 25-hydroxyvitamin D concentration of 19 ng/mL. No breakpoints were found for ionised calcium, total calcium or phosphorus. Conclusions These results suggest that a serum 25-hydroxyvitamin D concentration of 17 ng/mL serves as the threshold for vitamin D deficiency in rabbits. Nearly one-third of the rabbits had a serum 25-hydroxyvitamin D concentration below this threshold. Concerns persist regarding the high prevalence of vitamin D deficiency in pet rabbits and the possible health consequences caused by a chronic vitamin D deficiency, including the risk for metabolic bone diseases.
Subject: Rabbit
Vitamin D
25-hydroxyvitamin D
Parathyroid hormone
Calcium
Phosphorus
Bone density
Vitamin D deficiency
Metabolic bone disease
ULTRAVIOLET-B RADIATION
DENTAL DISEASE
ORYCTOLAGUS-CUNICULUS
HYPERPARATHYROIDISM
METABOLISM
CALCIUM
413 Veterinary science
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