Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

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Cameli, M.; Miglioranza, M.H.; Magne, J.; Mandoli, G.E.; Benfari, G.; Ancona, R.; Sibilio, G.; Reskovic Luksic, V.; Dejan, D.; Griseli, L.; Van De Heyning, C.M.; Mortelmans, P.; Michalski, B.; Kupczynska, K.; Di Giannuario, G.; Devito, F.; Dulgheru, R.; Ilardi, F.; Salustri, A.; Abushahba, G.; Morrone, D.; Fabiani, I.; Penicka, M.; Katbeh, A.; Sammarco, G.; Esposito, R.; Santoro, C.; Pastore, M.C.; Comenale Pinto, S.; Kalinin, A.; Pičkure, Ž.; Ažman Juvan, K.; Zupan Mežnar, A.; Coisne, A.; Coppin, A.; Opris, M.M.; Nistor, D.O.; Paakkanen, R.; Biering-Sørensen, T.; Olsen, F.J.; Lapinskas, T.; Vaškelyté, J.J.; Galian-Gay, L.; Casas, G.; Motoc, A.I.; Papadopoulos, C.H.; Loizos, S.; Ágoston, G.; Szabó, I.; Hristova, K.; Tsonev, S.N.; Galli, E.; Vinereanu, D.; Mihaila Baldea, S.; Muraru, D.; Mondillo, S.; Donal, E.; Galderisi, M.; Cosyns, B.; Edvardsen, T.; Popescu, B.A. Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study. Diagnostics 2020, 10, 946.

Title: Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study
Author: Cameli, Matteo; Miglioranza, Marcelo Haertel; Magne, Julien; Mandoli, Giulia Elena; Benfari, Giovanni; Ancona, Roberta; Sibilio, Gerolamo; Reskovic Luksic, Vlatka; Dejan, Dosen; Griseli, Leonardo; Van De Heyning, Caroline M.; Mortelmans, Philippe; Michalski, Blazej; Kupczynska, Karolina; Di Giannuario, Giovanna; Devito, Fiorella; Dulgheru, Raluca; Ilardi, Federica; Salustri, Alessandro; Abushahba, Galal; Morrone, Doralisa; Fabiani, Iacopo; Penicka, Martin; Katbeh, Asim; Sammarco, Giuseppe; Esposito, Roberta; Santoro, Ciro; Pastore, Maria Concetta; Comenale Pinto, Salvatore; Kalinin, Artem; Pičkure, Žanna; Ažman Juvan, Katja; Zupan Mežnar, Anja; Coisne, Augustine; Coppin, Amandine; Opris, Mihaela Maria; Nistor, Dan Octavian; Paakkanen, Riitta; Biering-Sørensen, Tor; Olsen, Flemming Javier; Lapinskas, Tomas; Vaškelyté, Jolanta Justina; Galian-Gay, Laura; Casas, Guillem; Motoc, Andreea Iulia; Papadopoulos, Constantinos Hristou; Loizos, Savvas; Ágoston, Gergely; Szabó, Istvan; Hristova, Krasimira; Tsonev, Svetlin Netkov; Galli, Elena; Vinereanu, Dragos; Mihaila Baldea, Sorina; Muraru, Denisa; Mondillo, Sergio; Donal, Erwan; Galderisi, Maurizio; Cosyns, Bernard; Edvardsen, Thor; Popescu, Bogdan A.
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2020-11-13
URI: http://hdl.handle.net/10138/322011
Abstract: Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume–pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.


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