Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells

Show full item record



Permalink

http://hdl.handle.net/10138/322027

Citation

Poon , W-L , Lee , J C-Y , Leung , K S , Alenius , H , El-Nezami , H & Karisola , P 2020 , ' Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells ' , Nanotoxicology , vol. 14 , no. 4 , pp. 453-467 . https://doi.org/10.1080/17435390.2019.1687776

Title: Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells
Author: Poon, Wing-Lam; Lee, Jetty Chung-Yung; Leung, Kin Sum; Alenius, Harri; El-Nezami, Hani; Karisola, Piia
Other contributor: University of Helsinki, HUMI - Human Microbiome Research
University of Helsinki, HUMI - Human Microbiome Research



Date: 2020-04-20
Language: eng
Number of pages: 15
Belongs to series: Nanotoxicology
ISSN: 1743-5390
DOI: https://doi.org/10.1080/17435390.2019.1687776
URI: http://hdl.handle.net/10138/322027
Abstract: Bioactive, oxygenated metabolites of polyunsaturated fatty acids (PUFAs) are important indicators of inflammation and oxidative stress but almost nothing is known about their interactions with nanomaterials (NMs). To investigate the effects of nano-sized materials (n-TiO2, n-ZnO, n-Ag) and their bulk-sized or ionic (b-TiO2, b-ZnO, i-Ag) counterpart, we studied the status of oxidative stress and PUFA metabolism in THP-1 cells at low-toxic concentrations (
Subject: Nanoparticles
metal oxides
fatty acid metabolism
LC
MS
microarray analysis
GLUTATHIONE
NANOPARTICLES
METAL
NANOTOXICITY
TRANSPORTERS
MACROPHAGES
HOMEOSTASIS
METABOLISM
MONOCYTES
TOXICITY
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Nanosized_silver_but_not_titanium.pdf 1.945Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record