Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells
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Poon , W-L , Lee , J C-Y , Leung , K S , Alenius , H , El-Nezami , H & Karisola , P 2020 , ' Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells ' , Nanotoxicology , vol. 14 , no. 4 , pp. 453-467 . https://doi.org/10.1080/17435390.2019.1687776
| Title: | Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells |
| Author: | Poon, Wing-Lam; Lee, Jetty Chung-Yung; Leung, Kin Sum; Alenius, Harri; El-Nezami, Hani; Karisola, Piia |
| Contributor organization: | HUMI - Human Microbiome Research University of Helsinki Research Programs Unit Staff Services |
| Date: | 2020-04-20 |
| Language: | eng |
| Number of pages: | 15 |
| Belongs to series: | Nanotoxicology |
| ISSN: | 1743-5390 |
| DOI: | https://doi.org/10.1080/17435390.2019.1687776 |
| URI: | http://hdl.handle.net/10138/322027 |
| Abstract: | Bioactive, oxygenated metabolites of polyunsaturated fatty acids (PUFAs) are important indicators of inflammation and oxidative stress but almost nothing is known about their interactions with nanomaterials (NMs). To investigate the effects of nano-sized materials (n-TiO2, n-ZnO, n-Ag) and their bulk-sized or ionic (b-TiO2, b-ZnO, i-Ag) counterpart, we studied the status of oxidative stress and PUFA metabolism in THP-1 cells at low-toxic concentrations ( |
| Subject: |
Nanoparticles
metal oxides fatty acid metabolism LC MS microarray analysis GLUTATHIONE NANOPARTICLES METAL NANOTOXICITY TRANSPORTERS MACROPHAGES HOMEOSTASIS METABOLISM MONOCYTES TOXICITY 3111 Biomedicine |
| Peer reviewed: | Yes |
| Rights: | cc_by_nc_nd |
| Usage restriction: | openAccess |
| Self-archived version: | acceptedVersion |
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Articles from TUHAT CRIS [52457]