Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells

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http://hdl.handle.net/10138/322027

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Poon , W-L , Lee , J C-Y , Leung , K S , Alenius , H , El-Nezami , H & Karisola , P 2020 , ' Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells ' , Nanotoxicology , vol. 14 , no. 4 , pp. 453-467 . https://doi.org/10.1080/17435390.2019.1687776

Titel: Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells
Författare: Poon, Wing-Lam; Lee, Jetty Chung-Yung; Leung, Kin Sum; Alenius, Harri; El-Nezami, Hani; Karisola, Piia
Upphovmannens organisation: HUMI - Human Microbiome Research
University of Helsinki
Research Programs Unit
Staff Services
Datum: 2020-04-20
Språk: eng
Sidantal: 15
Tillhör serie: Nanotoxicology
ISSN: 1743-5390
DOI: https://doi.org/10.1080/17435390.2019.1687776
Permanenta länken (URI): http://hdl.handle.net/10138/322027
Abstrakt: Bioactive, oxygenated metabolites of polyunsaturated fatty acids (PUFAs) are important indicators of inflammation and oxidative stress but almost nothing is known about their interactions with nanomaterials (NMs). To investigate the effects of nano-sized materials (n-TiO2, n-ZnO, n-Ag) and their bulk-sized or ionic (b-TiO2, b-ZnO, i-Ag) counterpart, we studied the status of oxidative stress and PUFA metabolism in THP-1 cells at low-toxic concentrations (
Subject: Nanoparticles
metal oxides
fatty acid metabolism
LC
MS
microarray analysis
GLUTATHIONE
NANOPARTICLES
METAL
NANOTOXICITY
TRANSPORTERS
MACROPHAGES
HOMEOSTASIS
METABOLISM
MONOCYTES
TOXICITY
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


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