Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells

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dc.contributor.author Poon, Wing-Lam
dc.contributor.author Lee, Jetty Chung-Yung
dc.contributor.author Leung, Kin Sum
dc.contributor.author Alenius, Harri
dc.contributor.author El-Nezami, Hani
dc.contributor.author Karisola, Piia
dc.date.accessioned 2020-11-27T02:46:26Z
dc.date.available 2021-12-18T03:46:02Z
dc.date.issued 2020-04-20
dc.identifier.citation Poon , W-L , Lee , J C-Y , Leung , K S , Alenius , H , El-Nezami , H & Karisola , P 2020 , ' Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells ' , Nanotoxicology , vol. 14 , no. 4 , pp. 453-467 . https://doi.org/10.1080/17435390.2019.1687776
dc.identifier.other PURE: 129594816
dc.identifier.other PURE UUID: 530a118d-a988-457d-99c6-de8d36544fd1
dc.identifier.other WOS: 000499048000001
dc.identifier.other ORCID: /0000-0003-0635-2704/work/76334351
dc.identifier.uri http://hdl.handle.net/10138/322027
dc.description.abstract Bioactive, oxygenated metabolites of polyunsaturated fatty acids (PUFAs) are important indicators of inflammation and oxidative stress but almost nothing is known about their interactions with nanomaterials (NMs). To investigate the effects of nano-sized materials (n-TiO2, n-ZnO, n-Ag) and their bulk-sized or ionic (b-TiO2, b-ZnO, i-Ag) counterpart, we studied the status of oxidative stress and PUFA metabolism in THP-1 cells at low-toxic concentrations ( en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Nanotoxicology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Nanoparticles
dc.subject metal oxides
dc.subject fatty acid metabolism
dc.subject LC
dc.subject MS
dc.subject microarray analysis
dc.subject GLUTATHIONE
dc.subject NANOPARTICLES
dc.subject METAL
dc.subject NANOTOXICITY
dc.subject TRANSPORTERS
dc.subject MACROPHAGES
dc.subject HOMEOSTASIS
dc.subject METABOLISM
dc.subject MONOCYTES
dc.subject TOXICITY
dc.subject 3111 Biomedicine
dc.title Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells en
dc.type Article
dc.contributor.organization HUMI - Human Microbiome Research
dc.contributor.organization University of Helsinki
dc.contributor.organization Research Programs Unit
dc.contributor.organization Staff Services
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1080/17435390.2019.1687776
dc.relation.issn 1743-5390
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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