Investigating the Survival Benefit of Combining Radiotherapy for Surgery Treated Locally Advanced Esophageal Squamous Cell Carcinoma Patients Aged 65 and Older

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Huang , S , Li , Y , Ma , H , Wang , W , Zheng , S , Ke , Y & Li , F 2019 , ' Investigating the Survival Benefit of Combining Radiotherapy for Surgery Treated Locally Advanced Esophageal Squamous Cell Carcinoma Patients Aged 65 and Older ' , Journal of Gastrointestinal Surgery , vol. 23 , no. 11 , pp. 2111-2118 . https://doi.org/10.1007/s11605-019-04200-5

Title: Investigating the Survival Benefit of Combining Radiotherapy for Surgery Treated Locally Advanced Esophageal Squamous Cell Carcinoma Patients Aged 65 and Older
Author: Huang, Shan; Li, Yuxing; Ma, Hongbing; Wang, Wenyu; Zheng, Shuyu; Ke, Yue; Li, Fang
Contributor organization: Institute for Molecular Medicine Finland
University of Helsinki
Date: 2019-11
Language: eng
Number of pages: 8
Belongs to series: Journal of Gastrointestinal Surgery
ISSN: 1091-255X
DOI: https://doi.org/10.1007/s11605-019-04200-5
URI: http://hdl.handle.net/10138/322089
Abstract: PurposeTo evaluate the survival benefit of combining radiotherapy with surgery in locally advanced esophageal squamous cell carcinoma (ESCC) patients aged over 65.MethodsUsing the SEER database, we selected patients age >= 65 years that were diagnosed as locally advanced ESCC during 2004-2013. Cancer-specific survival (CSS) was examined using the Kaplan-Meier analysis and compared by the log-rank test. Univariable and multivariable Cox proportional hazard models were established to identify possible prognostic factors.ResultsA total of 972 cases were included in the study. For surgical patients aged 65-79 years, 74 patients (32.9%) were treated by surgery alone and 122 patients (54.2%) had received additional neoadjuvant radiotherapy (NRT). NRT+surgery was associated with improved CSS comparing with surgery alone (HR, 0.58; 95%CI, 0.39 to 0.85; P=0.005). In subgroup analysis, NRT was associated with improved CSS for patients aged 65-74 years (2-year CSS 56.6% versus 39.6%, P=0.026). No significant differences of progonosis was observed for different treatment groups in 75-79 years patients (P=0.972).ConclusionsIn this SEER-based study, the addition of neoadjuvant radiotherapy before surgery was associated with improved CSS for locally advanced ESCC patients aged 65 to 74 years.
Subject: Esophageal squamous cell carcinoma
Aged 65 and older
Surgery
Radiotherapy
Survival
CANCER
CHEMORADIOTHERAPY
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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