Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock

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CardShock Investigators , Hongisto , M , Kataja , A , Tarvasmäki , T , Holopainen , A , Javanainen , T , Jurkko , R , Jäntti , T , Kimmoun , A , Levy , B , Mebazaa , A , Pulkki , K , Sionis , A , Tolppanen , H , Wollert , K C , Harjola , V-P & Lassus , J 2019 , ' Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock ' , Journal of Cardiac Failure , vol. 25 , no. 11 , pp. 894-901 . https://doi.org/10.1016/j.cardfail.2019.07.003

Title: Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock
Author: CardShock Investigators; Hongisto, Mari; Kataja, Anu; Tarvasmäki, Tuukka; Holopainen, Anu; Javanainen, Tuija; Jurkko, Raija; Jäntti, Toni; Kimmoun, Antoine; Levy, Bruno; Mebazaa, Alexandre; Pulkki, Kari; Sionis, Alessandro; Tolppanen, Heli; Wollert, Kai C.; Harjola, Veli-Pekka; Lassus, Johan
Other contributor: University of Helsinki, HUS Emergency Medicine and Services
University of Helsinki, HUS Emergency Medicine and Services
University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Department of Medicine
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Emergency Medicine and Services
University of Helsinki, HUS Heart and Lung Center






Date: 2019-11
Language: eng
Number of pages: 8
Belongs to series: Journal of Cardiac Failure
ISSN: 1071-9164
DOI: https://doi.org/10.1016/j.cardfail.2019.07.003
URI: http://hdl.handle.net/10138/322098
Abstract: Background: The aim of this study was to assess the levels, kinetics, and prognostic value of growth differentiation factor 15 (GDF-15) in cardiogenic shock (CS). Methods and Results: Levels of GDF-15 were determined in serial plasma samples (0-120 h) from 177 CS patients in the CardShock study. Kinetics of GDF-15, its association with 90-day mortality, and incremental value for risk stratification were assessed. The median GDF-15(0h) level was 9647 ng/L (IQR 4500-19,270 ng/L) and levels above median were significantly associated with acidosis, hyperlactatemia, renal dysfunction, and higher 90-day mortality (56% vs 28%, P7000 ng/L was identified as a strong predictor of death (OR 5.0; 95% CI 1.9-3.8, P=.002). Adding GDF-15(12h) >7000 ng/L to the CardShock risk score improved discrimination and risk stratification for 90-day mortality. Conclusions: GDF-15 levels are highly elevated in CS and associated with markers of systemic hypoperfusion and end-organ dysfunction. GDF-15 helps to discriminate survivors from non-survivors very early in CS.
Subject: Cardiogenic shock
growth differentiation factor 15 (GDF-15)
prognosis
biomarkers
CHRONIC HEART-FAILURE
BIOMARKERS
ASSOCIATION
INSIGHTS
UTILITY
SCORE
AGE
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
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