Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock

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CardShock Investigators , Hongisto , M , Kataja , A , Tarvasmäki , T , Holopainen , A , Javanainen , T , Jurkko , R , Jäntti , T , Kimmoun , A , Levy , B , Mebazaa , A , Pulkki , K , Sionis , A , Tolppanen , H , Wollert , K C , Harjola , V-P & Lassus , J 2019 , ' Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock ' , Journal of Cardiac Failure , vol. 25 , no. 11 , pp. 894-901 . https://doi.org/10.1016/j.cardfail.2019.07.003

Title: Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock
Author: CardShock Investigators; Hongisto, Mari; Kataja, Anu; Tarvasmäki, Tuukka; Holopainen, Anu; Javanainen, Tuija; Jurkko, Raija; Jäntti, Toni; Kimmoun, Antoine; Levy, Bruno; Mebazaa, Alexandre; Pulkki, Kari; Sionis, Alessandro; Tolppanen, Heli; Wollert, Kai C.; Harjola, Veli-Pekka; Lassus, Johan
Contributor organization: HUS Emergency Medicine and Services
Department of Diagnostics and Therapeutics
University of Helsinki
Clinicum
HUS Heart and Lung Center
Kardiologian yksikkö
Department of Medicine
Date: 2019-11
Language: eng
Number of pages: 8
Belongs to series: Journal of Cardiac Failure
ISSN: 1071-9164
DOI: https://doi.org/10.1016/j.cardfail.2019.07.003
URI: http://hdl.handle.net/10138/322098
Abstract: Background: The aim of this study was to assess the levels, kinetics, and prognostic value of growth differentiation factor 15 (GDF-15) in cardiogenic shock (CS). Methods and Results: Levels of GDF-15 were determined in serial plasma samples (0-120 h) from 177 CS patients in the CardShock study. Kinetics of GDF-15, its association with 90-day mortality, and incremental value for risk stratification were assessed. The median GDF-15(0h) level was 9647 ng/L (IQR 4500-19,270 ng/L) and levels above median were significantly associated with acidosis, hyperlactatemia, renal dysfunction, and higher 90-day mortality (56% vs 28%, P7000 ng/L was identified as a strong predictor of death (OR 5.0; 95% CI 1.9-3.8, P=.002). Adding GDF-15(12h) >7000 ng/L to the CardShock risk score improved discrimination and risk stratification for 90-day mortality. Conclusions: GDF-15 levels are highly elevated in CS and associated with markers of systemic hypoperfusion and end-organ dysfunction. GDF-15 helps to discriminate survivors from non-survivors very early in CS.
Subject: Cardiogenic shock
growth differentiation factor 15 (GDF-15)
prognosis
biomarkers
CHRONIC HEART-FAILURE
BIOMARKERS
ASSOCIATION
INSIGHTS
UTILITY
SCORE
AGE
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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