Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock

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dc.contributor.author CardShock Investigators
dc.contributor.author Hongisto, Mari
dc.contributor.author Kataja, Anu
dc.contributor.author Tarvasmäki, Tuukka
dc.contributor.author Holopainen, Anu
dc.contributor.author Javanainen, Tuija
dc.contributor.author Jurkko, Raija
dc.contributor.author Jäntti, Toni
dc.contributor.author Kimmoun, Antoine
dc.contributor.author Levy, Bruno
dc.contributor.author Mebazaa, Alexandre
dc.contributor.author Pulkki, Kari
dc.contributor.author Sionis, Alessandro
dc.contributor.author Tolppanen, Heli
dc.contributor.author Wollert, Kai C.
dc.contributor.author Harjola, Veli-Pekka
dc.contributor.author Lassus, Johan
dc.date.accessioned 2020-11-30T01:26:09Z
dc.date.available 2021-12-18T03:46:02Z
dc.date.issued 2019-11
dc.identifier.citation CardShock Investigators , Hongisto , M , Kataja , A , Tarvasmäki , T , Holopainen , A , Javanainen , T , Jurkko , R , Jäntti , T , Kimmoun , A , Levy , B , Mebazaa , A , Pulkki , K , Sionis , A , Tolppanen , H , Wollert , K C , Harjola , V-P & Lassus , J 2019 , ' Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock ' , Journal of Cardiac Failure , vol. 25 , no. 11 , pp. 894-901 . https://doi.org/10.1016/j.cardfail.2019.07.003
dc.identifier.other PURE: 129685665
dc.identifier.other PURE UUID: 09452fb0-5f3e-48a1-b968-67115dd04e0c
dc.identifier.other WOS: 000501939800007
dc.identifier.uri http://hdl.handle.net/10138/322098
dc.description.abstract Background: The aim of this study was to assess the levels, kinetics, and prognostic value of growth differentiation factor 15 (GDF-15) in cardiogenic shock (CS). Methods and Results: Levels of GDF-15 were determined in serial plasma samples (0-120 h) from 177 CS patients in the CardShock study. Kinetics of GDF-15, its association with 90-day mortality, and incremental value for risk stratification were assessed. The median GDF-15(0h) level was 9647 ng/L (IQR 4500-19,270 ng/L) and levels above median were significantly associated with acidosis, hyperlactatemia, renal dysfunction, and higher 90-day mortality (56% vs 28%, P7000 ng/L was identified as a strong predictor of death (OR 5.0; 95% CI 1.9-3.8, P=.002). Adding GDF-15(12h) >7000 ng/L to the CardShock risk score improved discrimination and risk stratification for 90-day mortality. Conclusions: GDF-15 levels are highly elevated in CS and associated with markers of systemic hypoperfusion and end-organ dysfunction. GDF-15 helps to discriminate survivors from non-survivors very early in CS. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Journal of Cardiac Failure
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Cardiogenic shock
dc.subject growth differentiation factor 15 (GDF-15)
dc.subject prognosis
dc.subject biomarkers
dc.subject CHRONIC HEART-FAILURE
dc.subject BIOMARKERS
dc.subject ASSOCIATION
dc.subject INSIGHTS
dc.subject UTILITY
dc.subject SCORE
dc.subject AGE
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Levels of Growth Differentiation Factor 15 and Early Mortality Risk Stratification in Cardiogenic Shock en
dc.type Article
dc.contributor.organization HUS Emergency Medicine and Services
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization Kardiologian yksikkö
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.cardfail.2019.07.003
dc.relation.issn 1071-9164
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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