Mast cells and complement system: Ancient interactions between components of innate immunity

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Elieh Ali Komi , D , Shafaghat , F , Kovanen , P T & Meri , S 2020 , ' Mast cells and complement system: Ancient interactions between components of innate immunity ' , Allergy : European journal of allergy and clinical immunology , vol. 75 , no. 11 , pp. 2818-2828 . https://doi.org/10.1111/all.14413

Title: Mast cells and complement system: Ancient interactions between components of innate immunity
Author: Elieh Ali Komi, Daniel; Shafaghat, Farzaneh; Kovanen, Petri T.; Meri, Seppo
Contributor: University of Helsinki, Wihuri Research Institute
University of Helsinki, HUSLAB
Date: 2020-11
Language: eng
Number of pages: 11
Belongs to series: Allergy : European journal of allergy and clinical immunology
ISSN: 0105-4538
URI: http://hdl.handle.net/10138/322169
Abstract: Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules. The system's main biological functions include lysis, opsonization, and recruitment of phagocytes. MCs, beyond their classic role as master cells of allergic reactions, play a role in other settings, as well. Thus, MCs are considered as extrahepatic producers of complement proteins. They express various complement receptors, including those for C3a and C5a. C3a and C5a not only activate the C3aR and C5aR expressing MCs but also act as chemoattractants for MCs derived from different anatomic sites, such as from the bone marrow, human umbilical cord blood, or skin in vitro. Cross talk between MCs and complement is facilitated by the production of complement proteins by MCs and their activation by the MC tryptase. The coordinated activity between MCs and the complement system plays a key role, for example, in a number of allergic, cutaneous, and vascular diseases. At a molecular level, MCs and complement system interactions are based on the production of several complement zymogens by MCs and their activation by MC-released proteases. Additionally, at a cellular level, MCs act as potent effector cells of complement activation by expressing receptors for C3a and C5a through which their chemoattraction and activation are mediated by anaphylatoxins in a paracrine and autocrine fashion.
Subject: 3111 Biomedicine
C3aR
C5aR
inflammation
innate immunity
urticaria
ACTIVATION
PHAGOCYTOSIS
PROTEIN
PHOSPHORYLATION
RECEPTOR
FACTOR C5A
C3A
DISEASE
A-BETA
ANAPHYLATOXINS
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