Bobbing of Oxysterols : Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

Show full item record



Permalink

http://hdl.handle.net/10138/322175

Citation

Kulig , W , Mikkolainen , H , Olzynska , A , Jurkiewicz , P , Cwiklik , L , Hof , M , Vattulainen , I , Jungwirth , P & Rog , T 2018 , ' Bobbing of Oxysterols : Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes ' , Journal of Physical Chemistry Letters , vol. 9 , no. 5 , pp. 1118-1123 . https://doi.org/10.1021/acs.jpclett.8b00211

Title: Bobbing of Oxysterols : Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
Author: Kulig, Waldemar; Mikkolainen, Heikki; Olzynska, Agnieszka; Jurkiewicz, Piotr; Cwiklik, Lukasz; Hof, Martin; Vattulainen, Ilpo; Jungwirth, Pavel; Rog, Tomasz
Contributor: University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
Date: 2018-03-01
Language: eng
Number of pages: 11
Belongs to series: Journal of Physical Chemistry Letters
ISSN: 1948-7185
URI: http://hdl.handle.net/10138/322175
Abstract: Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.
Subject: CHOLESTEROL FLIP-FLOP
SIDE-CHAIN OXYSTEROLS
LIPID-MEMBRANES
PLASMA-MEMBRANE
ENDOPLASMIC-RETICULUM
OXYGEN PERMEABILITY
BILAYERS
SIMULATION
ORIENTATION
METABOLISM
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Preprint_Final_Revision_Bobbing_Kulig.pdf 1.017Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record